Promising new photon detection concepts for high-resolution clinical and preclinical PET.
Promising new photon detection concepts for high-resolution clinical and preclinical PET.
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DOI：
10.2967/jnumed.110.084343
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Levin CS
中科院分区：
文献类型：
--
作者：
Levin CS
PET显像和量化低浓度PET示踪剂区域的能力代表了疾病的细微细胞和分子特征，这取决于相对复杂的生化、生物和生理因素，这些因素难以控制，以及仪器性能参数，原则上仍有可能改进，因此，后者的进步可以在一定程度上抵消前者的障碍。PET系统性能参数，如空间分辨率、对比度分辨率和光子灵敏度，对PET在背景存在下可视化和量化较低浓度信号的能力有重要贡献。在这份报告中，我们提出了一些技术创新的调查，以改善这些PET系统的性能参数。我们特别关注被称为三维位置敏感探测器的一个有前途的进步，这是能够区分和测量的位置，能量和到达时间的个人相互作用的多相互作用光子事件在3维的探测器。如果成功的话，这些新的策略能够增强诸如检测组织中更少的病变细胞或表征细胞内低丰度分子靶标的能力。将这些先进的功能应用于临床可能会扩大PET在疾病管理中的作用，也许会扩展到疾病的早期阶段。在临床前研究中，这种增强使活体疾病生物学研究更加灵敏和准确。
The ability of PET to visualize and quantify regions of low concentration of PET tracer representing subtle cellular and molecular signatures of disease depends on relatively complex biochemical, biologic, and physiologic factors that are challenging to control, as well as on instrumentation performance parameters that are, in principle, still possible to improve on. Thus, advances to the latter can somewhat offset barriers of the former. PET system performance parameters such as spatial resolution, contrast resolution, and photon sensitivity contribute significantly to PET’s ability to visualize and quantify lower concentrations of signal in the presence of background. In this report we present some technology innovations under investigation toward improving these PET system performance parameters. We focus particularly on a promising advance known as 3-dimensional position-sensitive detectors, which are detectors capable of distinguishing and measuring the position, energy, and arrival time of individual interactions of multi-interaction photon events in 3 dimensions. If successful, these new strategies enable enhancements such as the detection of fewer diseased cells in tissue or the ability to characterize lower-abundance molecular targets within cells. Translating these advanced capabilities to the clinic might allow expansion of PET’s roles in disease management, perhaps to earlier stages of disease. In preclinical research, such enhancements enable more sensitive and accurate studies of disease biology in living subjects.
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影响因子：
3.5
作者：
Spanoudaki, V. Ch;Levin, C. S.
通讯作者：
Levin, C. S.
影响因子：
2.8
作者：
Peng BH;Levin CS
通讯作者：
Levin CS
影响因子：
3.8
作者：
Gu, Yi;Pratx, Guillem;Levin, Craig S.
通讯作者：
Levin, Craig S.
影响因子：
3.5
作者：
Gu Y;Matteson JL;Skelton RT;Deal AC;Stephan EA;Duttweiler F;Gasaway TM;Levin CS
通讯作者：
Levin CS
影响因子：
3.5
作者：
Habte, F.;Foudray, A. M. K.;Levin, C. S.
通讯作者：
Levin, C. S.