Biological implications of androgen dependent changes in proton‐NMR relaxation times in rat ventral prostate
Biological implications of androgen dependent changes in proton‐NMR relaxation times in rat ventral prostate
复制标题
大鼠腹侧前列腺质子核磁共振弛豫时间雄激素依赖性变化的生物学意义
DOI：
10.1002/pros.2990090307
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
L. Glodé
中科院分区：
文献类型：
--
作者：
P. Braunschweiger;E. Maring;Katy Machus;K. Reynolds;L. Glodé
本研究在大鼠腹侧前列腺中进行，以确定质子核磁共振（1H-NMR）是否可能是监测消融和重建后雄激素依赖性靶组织生理变化的有用工具。去势后前列腺重量和血流量（86 RbCl分布）明显减少。虽然前列腺含水量不受雄激素消融的影响，但在切除的前列腺组织上测定的1H-NMR自旋晶格（T1）和自旋自旋（T2）弛豫时间分别减少了10%和50%。丙酸睾酮（TP）重建导致总含水量迅速但短暂的增加，前列腺血流量显着增加，腺体再生。1H-NMR研究表明，尽管Tp后T1延长与前列腺水含量的变化在时间上相关，但在总前列腺水含量恢复到对照水平后，T1仍然延长。在雄激素重建大鼠中，钆-DTPA-二甲基葡糖胺对前列腺T1的Gd-DTPA-dimeg修饰增加，表明前列腺细胞外水体积在T1增加的间隔期间显著增加。TP后前列腺T2弛豫时间的恢复相对于T1、水含量和前列腺血流量的变化延迟，但与前列腺干重的增加在时间上相关。评估Gd-DTPA-dimeg T2修饰的研究表明，雄激素耗竭和替代后的前列腺T2变化反映了体内Gd-DTPA-dimeg分布体积外的水质子的自旋-自旋弛豫。
The present studies were conducted in rat ventral prostate to determine if proton nuclear magnetic resonance (1H‐NMR) might be a useful tool to monitor physiologic changes in an androgen‐dependent target tissue after ablation and reconstitution. Ventral prostate mass and blood flow (86RbCl distribution) decreased markedly after castration. Although prostate water content was not affected by androgen ablation, 1H‐NMR spin‐lattice (T1) and spin‐spin (T2) relaxation times determined on excised prostate tissue were reduced by 10% and 50%, respectively. Testosterone propionate (Tp) reconstitution resulted in a prompt but transient increase in total water content, marked increases in prostate blood flow, and regrowth of the gland. 1H‐NMR studies indicated that although T1 lengthening after Tp was temporally related to changes in prostate water content, T1's remained prolonged after total prostate water content returned to control levels. Increased Gd‐DTPA‐dimeg modification of prostate T1 by Gadolinium‐DTPA‐dimethyl glucamine in androgen reconstituted rats implied that prostate extracellular water volumes were markedly increased during intervals of increased T1. Recovery of prostate T2 relaxation times after Tp was delayed with respect to changes in T1, water content, and prostate blood flow, but was temporally correlated with increase in prostate dry mass. Studies to assess Gd‐DTPA‐dimeg T2 modification showed that prostate T2 changes after androgen depletion and replacement reflected spin‐spin relaxation of water protons outside the in vivo Gd‐DTPA‐dimeg distribution volume.
Dunning R3327H 前列腺癌实验模型对雄激素消耗和补充条件的增殖反应。
影响因子：
11.2
作者：
English,HF;Kloszewski,ED;Valentine,EG;Santen,RJ
通讯作者：
Santen,RJ
实验性乳腺癌 MR 成像中的 Gd-DTPA 对比增强和组织分化。
影响因子：
19.7
作者：
Revel,D;Brasch,RC;Paajanen,H;Rosenau,W;Grodd,W;Engelstad,B;Fox,P;Winkelhake,J
通讯作者：
Winkelhake,J
地塞米松对 RIF-1 肿瘤血管功能的影响。
影响因子：
11.2
作者：
Braunschweiger,PG;Schiffer,LM
通讯作者：
Schiffer,LM