Pre-operative to post-operative serum carcinoembryonic antigen ratio is a prognostic indicator in colorectal cancer.
Pre-operative to post-operative serum carcinoembryonic antigen ratio is a prognostic indicator in colorectal cancer.
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DOI：
10.18632/oncotarget.17931
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发表时间：
2017-08-15
期刊：
影响因子：
--
通讯作者：
Yuan W
中科院分区：
文献类型：
--
作者：
Sun Z;Wang F;Zhou Q;Yang S;Sun X;Wang G;Li Z;Zhang Z;Song J;Liu J;Yuan W
我们探讨了大肠癌（CRC）术前与术后血清癌胚抗原（pre-post-CEA）比值的预后意义。我们检测了2001年6月至2011年6月在郑州大学第一附属医院接受手术治疗的2035例结直肠癌患者的术前和术后CEA水平。单因素分析显示cea前后比值与远处转移和肿瘤分化程度相关（P < 0.05）。多因素分析显示cea前后比值与淋巴结转移、远处转移、TNM分期及肿瘤分化程度相关（均P < 0.01）。多因素分析表明，cea前期水平、cea前后比值、远处转移、TNM分期、肿瘤分化程度与5年总生存率相关（均P < 0.05）。因此，cea前期水平、cea前后比值、远处转移和TNM分期是结直肠癌的独立危险因素。因此，我们已经证明cea前后比值是结直肠癌患者的预后指标。
We explored the prognostic significance of the pre-operative-to-post-operative serum carcinoembryonic antigen (pre-post-CEA) ratio in colorectal cancer (CRC). We detected pre- and post-operative CEA levels in 2035 CRC patients surgically treated at First Affiliated Hospital of Zhengzhou University between June 2001 and June 2011. Univariate analysis revealed the pre-post-CEA ratio is associated with distant metastasis and degree of tumor differentiation (both P < 0.05). Multivariate analysis showed that the pre-post-CEA ratio is associated with lymphatic and distant metastasis, tumor-node-metastasis (TNM) stage and degree of tumor differentiation (all P < 0.01). The pre-CEA levels, pre-post-CEA ratios, distant metastasis, TNM stage and degree of tumor differentiation were all associated with 5-yr overall survival (all P < 0.05) based on multivariate analysis. Consequently, pre-CEA levels, pre-post-CEA ratios, distant metastasis and TNM stage are independent risk factors for CRC. We have thus demonstrated that the pre-post-CEA ratio is a prognostic indicator for CRC patients.
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CEA-/lo结直肠癌细胞群含有癌症干细胞和转移细胞。
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