The Fate of Erythrocytes after Cerebral Hemorrhage.
The Fate of Erythrocytes after Cerebral Hemorrhage.
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DOI：
10.1007/s12975-021-00980-8
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发表时间：
2022-10
影响因子：
6.9
通讯作者：
Hua, Ya
中科院分区：
文献类型：
--
作者：
Xia, Fan;Keep, Richard F.;Ye, Fenghui;Holste, Katherine G.;Wan, Shu;Xi, Guohua;Hua, Ya
脑出血（脑内、蛛网膜下腔和脑室内）后，外渗血液通过物理破坏和质量效应导致初始脑损伤，并通过释放潜在的神经毒性和促炎因子（如血红蛋白、铁和过氧化物酶-2）导致继发性损伤。红细胞是主要的血液成分，并且是这种破坏性因素的来源。脑出血后红细胞溶解释放潜在的神经毒素，导致脑损伤和水肿。或者，通过小胶质细胞或巨噬细胞的红细胞吞噬作用可以限制神经毒素的溢出，从而限制随后的脑损伤。本文就脑出血后红细胞被小胶质细胞或巨噬细胞吞噬的过程、红细胞溶解对脑损伤的影响、红细胞和巨噬细胞从脑中排出的新机制以及在这一途径中寻找新的靶点以减轻脑损伤的研究进展作一综述。了解脑出血后红细胞的命运可能会发现临床转化研究的其他潜在干预措施。
After a cerebral hemorrhage (intracerebral, subarachnoid, and intraventricular), extravasated blood contributes to both initial brain injury, via physical disruption and mass effect, and secondary injury, through the release of potentially neurotoxic and pro-inflammatory factors such as hemoglobin, iron, and peroxiredoxin-2. Erythrocytes are a major blood component and are a source of such damaging factors. Erythrolysis after cerebral hemorrhage releases potential neurotoxins, contributing to brain injury and edema. Alternatively, erythrocyte phagocytosis via microglia or macrophages may limit the spill of neurotoxins therefore limiting subsequent brain injury. The aim of this review is to discuss the process of phagocytosis of erythrocytes by microglia or macrophages after cerebral hemorrhage, the effect of erythrolysis on brain injury, novel mechanisms of erythrocyte and phagocyte egress from the brain, and exciting new targets in this pathway to attenuate brain injury. Understanding the fate of erythrocytes after cerebral hemorrhage may uncover additional potential interventions for clinical translational research.
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