The presence of immunosuppressive ‘p15E‐like’ factors in the serum and urine of patients suffering from malign and benign breast tumours
The presence of immunosuppressive ‘p15E‐like’ factors in the serum and urine of patients suffering from malign and benign breast tumours
复制标题
患有恶性和良性乳腺肿瘤的患者的血清和尿液中存在免疫抑制“p15E 样”因子
DOI：
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复制
发表时间：
1993
影响因子：
4.6
通讯作者：
H. Drexhage
中科院分区：
文献类型：
--
作者：
H. Stöger;H. Stöger;M. Wilders;H. Samonigg;M. Schmid;T. Bauernhofer;A. Tiran;M. Tas;H. Drexhage
Certain types of tumours are capable of producing factors inhibiting mononuclear phagocyte chemotaxis which may contribute to defects in imtnunosurveillance. In head and neck cancer these factors are said to be related to the retroviral protein p15E. This study examines the presence of p15E‐like factors in serum and urine of patients with malign and benign breast tumours. Thirty patients with breast cancer, 29 patients with benign breast masses, and 28 healthy controls were tested blindly with the monocyte polarization assay, using N‐formyl‐methionyl‐leueylphenylalanine as chemoattractant. The low molecular weight fractions prepared of sera of the malign tumour patients inhibited the monocytc polarization significantly (mean inhibition 34%, s.d. = 12) compared with those of benign tumour patients (15%, s.d. = 7) and of controls (14%, s.d. = 6). The observed inhibitory effects on the monocyte polarization could be compensated by MoAbs reactive to p15E‐related antigens. The mean difference between the polarization inhibition with and without anti‐p15E adsorption (the ‘p15E‐likc factor‐induced inhibition’) was 25% (s.d. = 13) in the breast cancer group, compared with 7% (s.d. = 5) in the benign tumour patients and 5% (s.d. = 4) in the healthy control group. Surgical removal of the tumours resulted in a restoration of the monocytc polarization in 20/23 (87%) patients of the breast cancer group. Results testing preoperative urine samples correlated well with those of corresponding sera. These data give additional support to the concept that tumour‐derived p15E‐like factors are responsible for the inhibitory effect on monocytc chemolaxis in breast cancer patients, and that these factors can be found in serum as well as in urine.
单核细胞对趋化刺激的反应性是可以对多种趋化剂作出反应的细胞亚群的特性。
DOI：
10.1172/jci110033
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Cianciolo,GJ;Snyderman,R
通讯作者：
Snyderman,R
通过与逆转录病毒蛋白 p15E 保守区域同源的合成肽抑制人类自然杀伤细胞活性。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Harris,DT;Cianciolo,GJ;Snyderman,R;Argov,S;Koren,HS
通讯作者：
Koren,HS