Mental Stress and Its Effects on Vascular Health.
Mental Stress and Its Effects on Vascular Health.
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DOI：
10.1016/j.mayocp.2022.02.004
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发表时间：
2022-05
影响因子：
8.9
通讯作者：
Lerman, Amir
中科院分区：
文献类型：
--
作者：
Sara, Jaskanwal Deep Singh;Toya, Takumi;Ahmad, Ali;Clark, Matthew M.;Gilliam, Wesley P.;Lerman, Lliach O.;Lerman, Amir
尽管在风险分层和管理方面取得了重大进展，但冠状动脉疾病仍然是发病和死亡的主要原因。这促使人们寻找可能提供新治疗靶点的替代非常规风险因素。社会心理压力或精神压力已成为心血管事件发生率较高的重要危险因素，尽管近年来我们对这一广泛而有趣的现象的理解有了很大的发展，但关于如何测量精神压力以及它如何影响身体健康，仍有很多东西需要学习。鉴于当前 2019 年冠状病毒病全球大流行及其现有的封锁和社交距离，了解与改变生活的事件和社会隔离相关的压力的潜在有害生物效应变得更加重要。在当前的审查中，我们的多学科团队从心理社会的角度讨论压力，旨在尽可能严格地定义心理压力；讨论压力可能介导心血管疾病的病理生理机制，特别关注其对血管健康的影响；概述通过血管生物标志物量化压力的现有方法和途径；概述社会心理压力源可能产生病理效应并最终通过神经内分泌免疫轴传导至脉管系统的机制；在研究心理压力对心血管健康的影响时，强调需要改进的领域，以完善临床研究中的现有方法；并讨论旨在减少精神压力有害影响的循证疗法，包括针对内皮功能障碍的疗法。为此，我们搜索了 PubMed 和 Google Scholar，以找到评估精神或社会心理压力与心血管疾病之间关系的研究，特别关注血管健康。搜索词包括“心肌缺血”、“冠状动脉疾病”、“精神压力”、“心理压力”、“精神*压力*”、“心理*压力*”和“心血管疾病*”。检索仅限于 1990 年至今在同行评审期刊上以英文发表的研究。为了确定我们的数据库检索策略未捕获的潜在研究，我们还检索了相关出版物和评论的参考书目中列出的研究。
Coronary artery disease continues to be a major cause of morbidity and mortality despite significant advances in risk stratification and management. This has prompted the search for alternative nonconventional risk factors that may provide novel therapeutic targets. Psychosocial stress, or mental stress, has emerged as an important risk factor implicated in a higher incidence of cardiovascular events, and although our understanding of this far ranging and interesting phenomenon has developed greatly over recent times, there is still much to be learned regarding how to measure mental stress and how it may impact physical health. With the current coronavirus disease 2019 global pandemic and its incumbent lockdowns and social distancing, understanding the potentially harmful biological effects of stress related to life-changing events and social isolation has become even more important. In the current review our multidisciplinary team discusses stress from a psychosocial perspective and aims to define psychological stress as rigorously as possible; discuss the pathophysiologic mechanisms by which stress may mediate cardiovascular disease, with a particular focus to its effects on vascular health; outline existing methods and approaches to quantify stress by means of a vascular biomarker; outline the mechanisms whereby psychosocial stressors may have their pathologic effects ultimately transduced to the vasculature through the neuroendocrine immunologic axis; highlight areas for improvement to refine existing approaches in clinical research when studying the consequences of psychological stress on cardiovascular health; and discuss evidence-based therapies directed at reducing the deleterious effects of mental stress including those that target endothelial dysfunction. To this end we searched PubMed and Google Scholar to identify studies evaluating the relationship between mental or psychosocial stress and cardiovascular disease with a particular focus on vascular health. Search terms included “myocardial ischemia,” “coronary artery disease,” “mental stress,” “psychological stress,” “mental∗ stress∗,” “psychologic∗ stress∗,” and “cardiovascular disease∗.” The search was limited to studies published in English in peer-reviewed journals between 1990 and the present day. To identify potential studies not captured by our database search strategy, we also searched studies listed in the bibliography of relevant publications and reviews.
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影响因子：
37.8
作者：
Blumenthal JA;Sherwood A;Smith PJ;Watkins L;Mabe S;Kraus WE;Ingle K;Miller P;Hinderliter A
通讯作者：
Hinderliter A
影响因子：
2.8
作者：
Alenezi, Fawaz;Brummett, Beverly H.;Jiang, Wei
通讯作者：
Jiang, Wei
影响因子：
5.3
作者：
Bernberg, Evelina;Ulleryd, Marcus A.;Bergstrom, Goran M. L.
通讯作者：
Bergstrom, Goran M. L.
影响因子：
168.9
作者：
Arrighi, JA;Burg, M;Soufer, R
通讯作者：
Soufer, R
影响因子：
64.8
作者：
Camell CD;Sander J;Spadaro O;Lee A;Nguyen KY;Wing A;Goldberg EL;Youm YH;Brown CW;Elsworth J;Rodeheffer MS;Schultze JL;Dixit VD
通讯作者：
Dixit VD