Accelerated senile amyloidosis induced by amyloidogenic Apoa-II gene shortens the life span of mice but does not accelerate the rate of senescence.
Accelerated senile amyloidosis induced by amyloidogenic Apoa-II gene shortens the life span of mice but does not accelerate the rate of senescence.
复制标题
淀粉样变性Apoa-II基因诱导的加速老年淀粉样变性会缩短小鼠的寿命，但不会加速衰老速度。
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
M. Hosokawa
中科院分区：
文献类型：
--
作者：
K. Higuchi;J. Wang;K. Kitagawa;T. Matsushita;K. Kogishi;H. Naiki;H. Kitado;M. Hosokawa
SAMP1菌株是加速衰老和严重老年性淀粉样变性的小鼠模型。我们研究了淀粉样蛋白载脂蛋白A-II基因（Apoa2c）对老年性淀粉样变性的影响，以及携带SAMPI菌株Apoa2c基因的同源小鼠（R1.P1-Apoa2c）的寿命和衰老进程。R1中检测到年龄相关和严重的淀粉样蛋白沉积。P1-Apoa2c，寿命比SAMR1短20%。随着年龄的增长，R1的衰老评分增加得更快。P1-Apoa2c比SAMR1， Gompertz函数Y截距更大，但回归线斜率相同。这些结果表明，Apoa2c基因诱导的严重老年性淀粉样变会缩短小鼠的寿命，但不会加速衰老速度。
The SAMP1 strain is a mouse model for accelerated senescence and severe senile amyloidosis. We studied the effects of the amyloidogenic apolipoprotein A-II gene (Apoa2c) on senile amyloidosis and the life span and progress of senescence of congenic mice (R1.P1-Apoa2c) which have Apoa2c of the SAMPI strain on the genome of the normally aging SAMR1 strain. Age-associated and severe amyloid deposits were detected in R1.P1-Apoa2c, as well as a 20% shorter life span than that of SAMR1. The scores of senescence increased more rapidly with age in R1.P1-Apoa2c than that of SAMR1, and the Gompertz function showed a bigger Y intercept but the same slope of regression line. These results suggest that severe senile amyloidosis induced by the Apoa2c gene shortens the life span of mice but does not accelerate the rate of senescence.
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影响因子：
3.3
作者：
Rebecca Gelman;Ada Watson;Roderick Bronson;Edmond J. Yunis
通讯作者：
Rebecca Gelman;Ada Watson;Roderick Bronson;Edmond J. Yunis
影响因子：
56.9
作者：
WARDEN, CH;HEDRICK, CC;LUSIS, AJ
通讯作者：
LUSIS, AJ
DOI：
10.1073/pnas.84.11.3763
发表时间：
1987-06-01
影响因子：
11.1
作者：
PAIGEN, B;MITCHELL, D;LEBOEUF, RC
通讯作者：
LEBOEUF, RC
影响因子：
56.9
作者：
ZHANG, SH;REDDICK, RL;MAEDA, N
通讯作者：
MAEDA, N
淀粉样蛋白增强负载因子巨噬细胞在淀粉样蛋白纤维形成中的作用。
DOI：
--
发表时间：
1990
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Shirahama,T;Miura,K;Ju,ST;Kisilevsky,R;Gruys,E;Cohen,AS
通讯作者：
Cohen,AS