Atorvastatin treatment modulates the interaction between leptin and adiponectin, and the clinical parameters in patients with type II diabetes.
Atorvastatin treatment modulates the interaction between leptin and adiponectin, and the clinical parameters in patients with type II diabetes.
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DOI：
10.3892/etm.2013.1347
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发表时间：
2013-12
影响因子：
2.7
通讯作者：
Khabour OF
中科院分区：
文献类型：
--
作者：
Al-Azzam SI;Alkhateeb AM;Alzoubi KH;Alzayadeen RN;Ababneh MA;Khabour OF
本研究的目的是研究阿托伐他汀治疗对2型糖尿病患者瘦素、脂联素和胰岛素抵抗水平的影响及其与临床参数的相关性。糖尿病患者（n=394）分为两组，包括161例接受20 mg/d阿托伐他汀（他汀组）的患者和233例未接受他汀类药物（无他汀组）的患者。结果显示，阿托伐他汀治疗糖尿病患者与瘦素、脂联素、瘦素/脂联素（L/A）比值或稳态模型评估-胰岛素抵抗（HOMA-IR）的变化无关。而低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）和总胆固醇（Tchol）仅在他汀组与瘦素和L/A比值呈正相关（P<0.05）。而他汀组和非他汀组高密度脂蛋白胆固醇（HDL-C）与脂联素呈显著正相关（P<0.05）。两组HOMA-IR与糖化血红蛋白（HbA 1c）、甘油三酯（TG）均呈正相关，而他汀组Tchol与HOMA-IR呈正相关（P<0.05）。以HOMA-IR作为因变量进行多变量分析，并校正年龄、体重指数（BMI）和腰围，发现HbA 1c是HOMA-IR或胰岛素抵抗的重要预测因子。总之，阿托伐他汀治疗可能对瘦素和脂联素之间的相互作用以及对II型糖尿病患者的临床参数有多种影响。
The aim of this study was to examine the effect of atorvastatin treatment on levels of leptin, adiponectin and insulin resistance, and their correlation with clinical parameters, in patients with type II diabetes. Patients with diabetes (n=394) were divided into two groups, comprising 161 patients who received 20 mg/day atorvastatin (statin group), and 233 patients who did not receive statins (statin-free group). The results showed that atorvastatin treatment of patients with diabetes was not associated with changes in leptin, adiponectin, the leptin/adiponectin (L/A) ratio or homeostasis model assessment-insulin resistance (HOMA-IR). However, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (Tchol) were positively correlated with leptin and L/A ratio in the statin group only (P<0.05). By contrast, high-density lipoprotein cholesterol (HDL-C) showed a significant positive correlation with adiponectin in the statin and statin-free groups (P<0.05). Additionally, a positive correlation was found between HOMA-IR and glycated hemoglobin (HbA1c), and TG, in both groups, whereas Tchol was positively correlated with HOMA-IR in the statin group only (P<0.05). When multivariate analysis was performed with HOMA-IR as the dependent variable, and with adjustment for age, body mass index (BMI) and waist circumference, HbA1c was found to be a significant predictor of HOMA-IR or insulin resistance. In conclusion, atorvastatin treatment may have several effects on the interaction between leptin and adiponectin, and on clinical parameters in patients with type II diabetes.
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影响因子：
5.3
作者：
Koh, Kwang Kon;Quon, Michael J.;Han, Seung Hwan;Lee, Yonghee;Kim, Soo Jin;Park, Jeong Beorn;Shin, Eak Kyun
通讯作者：
Shin, Eak Kyun
影响因子：
24
作者：
Koh, Kwang Kon;Quon, Michael J.;Han, Seung Hwan;Lee, Yonghee;Kim, Soo Jin;Shin, Eak Kyun
通讯作者：
Shin, Eak Kyun
影响因子：
168.9
作者：
Sattar, Naveed;Preiss, David;Ford, Ian
通讯作者：
Ford, Ian
影响因子：
2.8
作者：
Navarese, Eliano Pio;Buffon, Antonino;Kubica, Jacek
通讯作者：
Kubica, Jacek
DOI：
10.1590/s0104-42302009000300030
发表时间：
2009-01-01
期刊：
Revista da Associação Médica Brasileira
影响因子：
--
作者：
Vasques, Ana Carolina Junqueira;Rosado, Lina Enriqueta Frandsen Paez de Lima;Oliveira, Dirce Ribeiro de
通讯作者：
Oliveira, Dirce Ribeiro de