Central cholinergic involvement in sequential behavior: impairments of performance by atropine in a serial multiple choice task for rats.
Central cholinergic involvement in sequential behavior: impairments of performance by atropine in a serial multiple choice task for rats.
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DOI：
10.1016/j.nlm.2013.07.009
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发表时间：
2013-11
影响因子：
2.7
通讯作者：
Wollan, Michael O.
中科院分区：
文献类型：
--
作者：
Fountain, Stephen B.;Rowan, James D.;Wollan, Michael O.
关键词：
两个实验研究了毒蕈碱胆碱能系统是否在大鼠进行良好学习的高度结构化的系列反应模式的能力中发挥作用，特别关注大鼠通过编码规则与通过获得刺激-反应（S-R）关联学习的模式元素的表现。大鼠在一个连续的多项选择任务中进行了一系列的反应模式，在一个8杠杆圆形阵列的下丘脑脑刺激奖励。两个实验研究了阿托品（一种中枢作用的毒蕈碱胆碱能受体拮抗剂）对大鼠执行模式元素的能力的影响，其中反应由规则与元素控制，例如规则不一致的“违规元素”和“措辞提示”元素，其中反应由联想提示控制。在实验1中，这两种模式的3个元素块的停顿，作为措辞线索之前块边界元素，但一个模式还包括一个违规元素，是不一致的模式结构。一旦大鼠达到高性能标准，则通过腹腔内注射单剂量50 mg/kg硫酸阿托品进行药物激发。阿托品对S-R学习中的组块边界元素和违反元素的学习成绩有影响，但对规则组块内元素的学习成绩没有影响。在实验2中，模式是短语化和非短语化的完美模式（即，没有违规行为）。为了控制阿托品的外周效应，大鼠接受了一系列剂量的中枢作用阿托品或外周作用阿托品硝酸甲酯（AMN）治疗，这些药物不会穿过血脑屏障。一旦大鼠达到高标准，药物激发是在隔日的顺序50，25和100 mg/kg的硫酸阿托品或AMN。阿托品，但不是AMN，受损的表现在措辞完美的模式的模式元素，S-R协会是重要的性能，即，块边界元素。然而，在结构上更模糊的unphrased完美模式中，大鼠的线索更少，可能更依赖于S-R协会，阿托品损害了所有模式元素的表现。因此，完整的毒蕈碱胆碱能系统被证明是必要的判别控制先前建立的S-R学习，但没有必要的规则为基础的串行模式的性能。
Two experiments examined whether muscarinic cholinergic systems play a role in rats’ ability to perform well-learned highly-structured serial response patterns, particularly focusing on rats’ performance on pattern elements learned by encoding rules versus by acquisition of stimulus-response (S-R) associations. Rats performed serial patterns of responses in a serial multiple choice task in an 8-lever circular array for hypothalamic brain-stimulation reward. Two experiments examined the effects of atropine, a centrally-acting muscarinic cholinergic receptor antagonist, on rats’ ability to perform pattern elements where responses were controlled by rules versus elements, such as rule-inconsistent “violation elements” and elements following “phrasing cues,” where responses were controlled by associative cues. In Experiment 1, 3-element chunks of both patterns were signaled by pauses that served as phrasing cues before chunk-boundary elements, but one pattern also included a violation element that was inconsistent with pattern structure. Once rats reached a high criterion of performance, the drug challenge was intraperitoneal injection of a single dose of 50 mg/kg atropine sulfate. Atropine impaired performance on elements learned by S-R learning, namely, chunk-boundary elements and the violation element, but had no effect on performance of rule-based within-chunk elements. In Experiment 2, patterns were phrased and unphrased perfect patterns (i.e., without violation elements). To control for peripheral effects of atropine, rats were treated with a series of doses of either centrally-acting atropine or peripherally-acting atropine methyl nitrate (AMN), which does not cross the blood-brain barrier. Once rats reached a high criterion, the drug challenges were on alternate days in the order 50, 25, and 100 mg/kg of either atropine sulfate or AMN. Atropine, but not AMN, impaired performance in the phrased perfect pattern for pattern elements where S-R associations were important for performance, namely, chunk-boundary elements. However, in the structurally more ambiguous unphrased perfect pattern where rats had fewer cues and presumably relied more on S-R associations throughout, atropine impaired performance on all pattern elements. Thus, intact muscarinic cholinergic systems were shown to be necessary for discriminative control previously established by S-R learning, but were not necessary for rule-based serial pattern performance.
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影响因子：
1.4
作者：
Fountain, Stephen B.;Benson, Don M., Jr.
通讯作者：
Benson, Don M., Jr.
影响因子：
2.6
作者：
BOWER, GH
通讯作者：
BOWER, GH
影响因子：
3.4
作者：
COHN, J;ZIRIAX, JM;CORYSLECHTA, DA
通讯作者：
CORYSLECHTA, DA
DOI：
10.1037/0097-7403.21.3.187
发表时间：
1995-07-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
FOUNTAIN, SB;ROWAN, JD
通讯作者：
ROWAN, JD
DOI：
10.1037/0097-7403.16.1.96
发表时间：
1990-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
FOUNTAIN, SB
通讯作者：
FOUNTAIN, SB