Abrupt hippocampal remapping signals resolution of memory interference.
Abrupt hippocampal remapping signals resolution of memory interference.
复制标题
突然的海马区重新映射信号，记忆干扰的解决。
DOI：
10.1038/s41467-021-25126-0
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发表时间：
2021-08-10
影响因子：
16.6
通讯作者：
Kuhl BA
中科院分区：
文献类型：
--
作者：
Wanjia G;Favila SE;Kim G;Molitor RJ;Kuhl BA
重映射是指相似空间环境的海马表征的去相关。虽然有人推测重新映射可能有助于解决人类的情景记忆干扰，但直接证据非常有限。我们使用高分辨率的、基于模式的功能磁共振成像分析来测试这个想法。在这里，我们表明，在人类CA 3/齿状回的活动模式表现出一个突然的，时间特异性的高度相似的记忆表示，精确地耦合与成功的学习行为表达的去相关。这种与学习相关的去相关的幅度是通过学习初始阶段的模式重叠量来预测的，初始重叠越大，去相关性越强。最后，我们发现，重新映射的活动模式进行相对更多的信息学习情景协会相比，竞争协会，进一步验证了学习相关的意义重新映射。总的来说，这些发现建立了海马重新映射和情节记忆干扰之间的关键联系，并提供了为什么重新映射发生的见解。当两个记忆相似时，它们的编码和提取可能会被彼此干扰。在这里，作者表明，记忆干扰是通过人类海马CA 3区和齿状回的活动模式的突然重新映射来解决的。
Remapping refers to a decorrelation of hippocampal representations of similar spatial environments. While it has been speculated that remapping may contribute to the resolution of episodic memory interference in humans, direct evidence is surprisingly limited. We tested this idea using high-resolution, pattern-based fMRI analyses. Here we show that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning. The magnitude of this learning-related decorrelation was predicted by the amount of pattern overlap during initial stages of learning, with greater initial overlap leading to stronger decorrelation. Finally, we show that remapped activity patterns carry relatively more information about learned episodic associations compared to competing associations, further validating the learning-related significance of remapping. Collectively, these findings establish a critical link between hippocampal remapping and episodic memory interference and provide insight into why remapping occurs. When two memories are similar, their encoding and retrieval can be disrupted by each other. Here the authors show that memory interference is resolved through abrupt remapping of activity patterns in the human hippocampal CA3 and dentate gyrus.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
25
作者：
Julian, Joshua B.;Doeller, Christian F.
通讯作者：
Doeller, Christian F.
空间记忆之间的重叠会触发海马表示的排斥。
DOI：
10.1016/j.cub.2017.06.057
发表时间：
2017-08-07
期刊：
Current biology : CB
影响因子：
--
作者：
Chanales AJH;Oza A;Favila SE;Kuhl BA
通讯作者：
Kuhl BA