Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors
Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors
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相关骨髓或外周血干细胞捐献者的严重短期不良事件
DOI：
10.1007/s12185-022-03489-4
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tsukada N
中科院分区：
文献类型：
--
作者：
Yanagisawa R;Hirakawa T;Doki N;Ikegame K;Matsuoka K;Fukuda T;Nakamae H;Ota S;Hiramoto N;Ishikawa J;Ara T;Tanaka M;Koga Y;Kawakita T;Maruyama Y;Kanda Y;Hino M;Atsuta Y;Yabe H;Tsukada N
造血细胞移植供体中严重不良事件（SAE）的发生率和相关风险因素需要针对相关供体（移植受者的亲属）进行澄清，其捐献标准比无关供体更宽松。对2005年至2021年期间在日本国家数据登记数据库中登记的相关供体的数据进行了评估，以确定短期SAE发生率与登记时供体特征的相关性。10，684例外周血干细胞（PBSC）供体中有54例（0.32%）在短期捐献期间发生了经证实的SAE。未观察到死亡。既往病史是BM和PBSC供体中SAE的常见风险因素。年龄≥ 60岁和女性被确定为PBSC供体中SAE的风险因素。女性也是动员不良的一个危险因素，这导致了PBSC收集的中断。尽管供体应仔细选择，但在日本，相关供体有一定的安全性。应通过改进亲缘供者的选择方法和延长随访期来进一步提高供者的安全性。
The incidence of severe adverse events (SAEs) and associated risk factors in hematopoietic cell transplantation donors needs to be clarified for related donors (relatives of the transplant recipient), whose criteria for donation are more lenient than for unrelated donors. Data from related donors registered in the Japanese national data registry database between 2005 and 2021 were evaluated to determine the association of short-term SAE incidence with donor characteristics at registration.Fourteen of 4339 bone marrow (BM) donors (0.32%) and 54 of 10,684 peripheral blood stem cell (PBSC) donors (0.51%) experienced confirmed SAEs during the short donation period. No deaths were observed. Past medical history was a common risk factor for SAEs in both BM and PBSC donors. Age of 60 years or older and female sex were identified as risk factors for SAEs in PBSC donors. Female sex was also a risk factor for poor mobilization, which resulted in discontinuation of PBSC collection.Although donors should be selected carefully, a certain level of safety is ensured for related donors in Japan. Donor safety should be further increased by improving the selection method for related donors and extending the follow-up period.
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同种异体造血干细胞移植：供者的注意事项。
影响因子：
20.3
作者：
P. Anderlini;M. Korbling;David C. Dale;A. Gratwohl;N. Schmitz;D. Stroncek;C. W. Howe;S. Leitman;M. Horowitz;Eliane Gluckman;S. Rowley;D. Przepiorka;R. Champlin
通讯作者：
R. Champlin
影响因子：
4.8
作者：
Halter, J. P.;van Walraven, S. M.;Confer, D.
通讯作者：
Confer, D.
影响因子：
4.8
作者：
Maiers, M.;Bakker, J. N. A.;Rist, H-G
通讯作者：
Rist, H-G
影响因子：
20.3
作者：
Hoelig, Kristina;Kramer, Michael;Ehninger, Gerhard
通讯作者：
Ehninger, Gerhard
影响因子：
4.8
作者：
Murata, M;Harada, M;Kodera, Y
通讯作者：
Kodera, Y