Peak I of the human auditory brainstem response results from the somatic regions of type I spiral ganglion cells: evidence from computer modeling.
Peak I of the human auditory brainstem response results from the somatic regions of type I spiral ganglion cells: evidence from computer modeling.
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DOI：
10.1016/j.heares.2014.07.001
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发表时间：
2014-09
期刊：
影响因子：
2.8
通讯作者：
Danner, Simon M.
中科院分区：
文献类型：
--
作者：
Rattay, Frank;Danner, Simon M.
听觉脑干反应（ABR）是听觉系统对声音信号的早期反应，可以被电记录为一系列波，称为听觉脑干反应（ABR）。ABR波的潜伏期对临床和神经生理学评价具有重要意义。利用螺旋神经节细胞跨膜电流沿着的生物物理模型，我们发现：（i）在人类中，I型细胞的无髓鞘体细胞区（支配内毛细胞）主要贡献I峰，（ii）I型细胞的超强突触后刺激电流（400 pA）和有髓鞘外周轴突的跨膜电流要小一个数量级;这样的突触后电流对应于小的可记录ABR峰I '的短时间，（iii）双极I型细胞的中央轴突的ABR信号参与比它们的外周对应物更有效，因为加倍的直径引起更大的跨膜电流和更大的尖峰偶极子长度，（iv）神经支配外毛细胞的II型细胞的无髓鞘纤维产生基本上更大的跨膜电流，但它们的ABR贡献很小，因为II型/I型细胞的比例小、放电率低和在无髓鞘纤维中缓慢传播的短偶极子长度的尖峰。使用简化头部的有限元模型，In峰和II峰（其中In是峰I之后的负峰）被发现是当尖峰的齐射穿过在骨和硬脑膜/CSF处和在CSF/CSF处的外部导电屏障时的稳定电位。而I'和I峰可能由I型远端和索马区的强局部跨膜电流作为突触后事件产生单元格。所有模拟的人体峰间时间（I-I′、II-I、In-I）均接近已发表的数据。ABR峰I由来自I型螺旋神经节细胞的跨膜电流产生。人I型细胞的最大跨膜电流来自索马区。最大跨膜电流产生ABR峰I。峰I时间与细胞外介质的电导无关。因此，峰I不是与峰II相反的固定电势。
Early neural responses to acoustic signals can be electrically recorded as a series of waves, termed the auditory brainstem response (ABR). The latencies of the ABR waves are important for clinical and neurophysiological evaluations. Using a biophysical model of transmembrane currents along spiral ganglion cells, we show that in human (i) the non-myelinated somatic regions of type I cells, which innervate inner hair cells, predominantly contribute to peak I, (ii) the supra-strong postsynaptic stimulating current (400 pA) and transmembrane currents of the myelinated peripheral axons of type I cells are an order smaller; such postsynaptic currents correspond to the short latencies of a small recordable ABR peak I’, (iii) the ABR signal involvement of the central axon of bipolar type I cells is more effective than their peripheral counterpart as the doubled diameter causes larger transmembrane currents and a larger spike dipole-length, (iv) non-myelinated fibers of type II cells which innervate the outer hair cells generate essentially larger transmembrane currents but their ABR contribution is small because of the small ratio type II/type I cells, low firing rates and a short dipole length of spikes propagating slowly in non-myelinated fibers. Using a finite element model of a simplified head, peaks In and II (where In is the negative peak after peak I) are found to be stationary potentials when volleys of spikes cross the external electrical conductivity barrier at the bone&dura/CSF and at the CSF/brainstem interface whereas peaks I’ and I may be generated by strong local transmembrane currents as postsynaptic events at the distal ending and the soma region of type I cells, respectively. All simulated human inter-peak times (I–I′, II–I, In–I) are close to published data. ABR peak I is generated by transmembrane currents from type I spiral ganglion cells. Maximum transmembrane currents in human type I cells are from the soma region. The maximum transmembrane currents generate ABR peak I. Peak I time is independent from the conductance of the extracellular media. Thus, peak I is not a stationary potential which is in contrast to peak II.
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影响因子：
2.8
作者：
ABBAS, PJ;BROWN, CJ
通讯作者：
BROWN, CJ
DOI：
10.1007/s10162-014-0447-y
发表时间：
2014-06-01
影响因子：
2.4
作者：
Lichtenhan, J. T.;Hartsock, J. J.;Salt, A. N.
通讯作者：
Salt, A. N.
影响因子：
5.3
作者：
Hossain, WA;Antic, SD;Morest, DK
通讯作者：
Morest, DK
DOI：
10.1016/0013-4694(70)90203-8
发表时间：
1970-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
JEWETT, DL
通讯作者：
JEWETT, DL
DOI：
10.1007/bf00453533
发表时间：
1982-01-01
期刊：
ARCHIVES OF OTO-RHINO-LARYNGOLOGY-ARCHIV FUR OHREN-NASEN-UND KEHLKOPFHEILKUNDE
影响因子：
--
作者：
GERSDORFF, MCH
通讯作者：
GERSDORFF, MCH