Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.
Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.
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DOI：
10.1038/s41398-021-01729-5
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发表时间：
2021-11-27
影响因子：
6.8
通讯作者：
Miller JM
中科院分区：
文献类型：
--
作者：
Smart K;Yttredahl A;Oquendo MA;Mann JJ;Hillmer AT;Carson RE;Miller JM
临床前研究表明kappa阿片受体(Kors)与应激反应和抑郁相关行为有关，但来自人类研究的证据有限。在这里，我们介绍了使用KOR放射性示踪剂[11C]GR103545进行正电子发射断层扫描所获得的数据的二次分析结果，这些数据来自10名未服药、目前患有抑郁症的患者(32.6 ± 6.5岁，5名女性)和13名健康志愿者(34.8 ± 10岁，6名女性)。独立成分分析被用来确定所有受试者KOR结合(示踪剂分布体积，VT)的相干方差的空间模式。每种成分的表达在不同组之间进行比较，并使用17个条目的汉密尔顿抑郁量表(HDRS)来探索与症状的关系。KOR可利用度在ROI之间的差异被识别为三个分量，空间特征由[11C]GR103545 VT在(1)双侧额叶；(2)枕叶和顶叶皮质、右侧海马体和壳核；以及(3)右侧前扣带回、右额上回和岛叶，加上左侧扣带回中部的负负荷。在MDD患者中，成分3与HDRS上的症状严重程度呈负相关(r = −为0.85，p = 为0.0021)。在患者和对照组之间，任何成分的表达在组内都没有差异。这些初步发现表明，与抑郁相关的皮质区域，特别是右前扣带回的KOR信号可能反映了MDD的病理生理学。
Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [11C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6 ± 6.5 years, 5 women) and 13 healthy volunteers (34.8 ± 10 years, 6 women). Independent component analysis was performed to identify spatial patterns of coherent variance in KOR binding (tracer volume of distribution, VT) across all subjects. Expression of each component was compared between groups and relationships to symptoms were explored using the 17-item Hamilton Depression Rating Scale (HDRS). Three components of variation in KOR availability across ROIs were identified, spatially characterized by [11C]GR103545 VT in (1) bilateral frontal lobe; (2) occipital and parietal cortices, right hippocampus, and putamen; and (3) right anterior cingulate, right superior frontal gyrus and insula, coupled to negative loading in left middle cingulate. In MDD patients, component 3 was negatively associated with symptom severity on the HDRS (r = −0.85, p = 0.0021). There were no group-wise differences in expression of any component between patients and controls. These preliminary findings suggest that KOR signaling in cortical regions relevant to depression, particularly right anterior cingulate, could reflect MDD pathophysiology.
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重度抑郁症和躁郁症患者内在大脑活动改变的常见和独特模式：基于体素的荟萃分析
影响因子：
6.8
作者：
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Wang Y
影响因子：
5.7
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Fang XT;Toyonaga T;Hillmer AT;Matuskey D;Holmes SE;Radhakrishnan R;Mecca AP;van Dyck CH;D'Souza DC;Esterlis I;Worhunsky PD;Carson RE
通讯作者：
Carson RE
影响因子：
5.7
作者：
Fink, Martin;Wadsak, Wolfgang;Lanzenberger, Rupert
通讯作者：
Lanzenberger, Rupert
影响因子：
10.6
作者：
de Laat, Bart;Goldberg, Alissa;Krishnan-Sarin, Suchitra
通讯作者：
Krishnan-Sarin, Suchitra
DOI：
10.1038/npp.2014.330
发表时间：
2015-05
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
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作者：
通讯作者：
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