DNA damage and lamins.
DNA damage and lamins.
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DOI：
10.1007/978-1-4899-8032-8_17
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发表时间：
2014
影响因子：
--
通讯作者：
Gonzalo S
中科院分区：
文献类型：
--
作者：
Gonzalo S
基因组的空间和时间组织已经成为核功能调节的额外水平。与核膜相关的结构蛋白在基因组的组织中起重要作用。核纤层是由核纤层蛋白（A型和B型）和核纤层蛋白相关蛋白形成的聚合物网络，被认为是束缚染色质和蛋白质复合物调节各种核功能的支架。核纤层蛋白功能的改变会影响DNA的转录、复制和修复，以及改变染色质结构的表观遗传修饰。这些数据以及缺陷核纤层蛋白与各种退行性疾病、早衰综合征和癌症的关联，为这些蛋白质充当基因组的看护者提供了证据。在这一章中，我们总结了目前的知识核纤层蛋白在维持基因组完整性的功能，特别强调的作用，A型核纤层蛋白在维持端粒稳态和DNA损伤修复的机制。这些发现已经开始阐明A型核纤层蛋白的改变诱导基因组不稳定性并有助于衰老和衰老相关疾病（特别是癌症）的病理生理学的分子机制。
The spatial and temporal organization of the genome has emerged as an additional level of regulation of nuclear functions. Structural proteins associated with the nuclear envelope play important roles in the organization of the genome. The nuclear lamina, a polymeric meshwork formed by lamins (A- and B-type) and lamin-associated proteins, is viewed as a scaffold for tethering chromatin and protein complexes regulating a variety of nuclear functions. Alterations in lamins function impact DNA transactions such as transcription, replication, and repair, as well as epigenetic modifications that change chromatin structure. These data, and the association of defective lamins with a whole variety of degenerative disorders, premature aging syndromes, and cancer, provide evidence for these proteins operating as caretakers of the genome. In this chapter, we summarize current knowledge about the function of lamins in the maintenance of genome integrity, with special emphasis on the role of A-type lamins in the maintenance of telomere homeostasis and mechanisms of DNA damage repair. These findings have begun to shed some light onto molecular mechanisms by which alterations in A-type lamins induce genomic instability and contribute to the pathophysiology of aging and aging-related diseases, especially cancer.
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影响因子：
7.5
作者：
Cremer, Thomas;Cremer, Marion;Fakan, Stanislav
通讯作者：
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影响因子：
21.3
作者：
Fernandez-Capetillo, O;Chen, HT;Nussenzweig, A
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DOI：
10.1073/pnas.192460799
发表时间：
2002-10-01
影响因子：
11.1
作者：
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通讯作者：
Young, SG
影响因子：
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作者：
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DOI：
10.1016/j.bbagen.2010.01.002
发表时间：
2010-04-01
影响因子：
3
作者：
De Vos, Winnok H.;Houben, Frederik;Van Oostveldt, Patrick
通讯作者：
Van Oostveldt, Patrick