Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons.
Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons.
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DOI：
10.3390/nu8120761
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发表时间：
2016-11-26
期刊：
影响因子：
5.9
通讯作者：
Samieri C
中科院分区：
文献类型：
--
作者：
Lefèvre-Arbogast S;Féart C;Dartigues JF;Helmer C;Letenneur L;Samieri C
B族维生素可以降低痴呆症的风险，但流行病学调查结果，主要来自叶酸强化的国家，仍然不一致。我们在一个大型的法国老年人队列中评估了饮食B族维生素与长期痴呆事件之间的关系。我们纳入了来自三城研究的1321名参与者，他们完成了24小时饮食回忆，在饮食评估时没有痴呆症，并接受了平均7.4年的随访。在校正了多个潜在混杂因素（包括总体饮食质量）的考克斯比例风险模型中，叶酸摄入量增加与痴呆风险呈负相关（趋势p = 0.02），叶酸摄入量最高的个体与叶酸摄入量最低的五分位数相比，痴呆风险降低约50%（HR = 0.47; 95%CI 0.28; 0.81）。没有发现维生素B6和B12的相关性。总之，在一个基线叶酸水平相对较低（平均摄入量= 278 μ g/天）的大型法国队列中，较高的叶酸摄入量与痴呆风险降低相关。
B vitamins may lower the risk of dementia, yet epidemiological findings, mostly from countries with folic acid fortification, have remained inconsistent. We evaluated in a large French cohort of older persons the associations between dietary B vitamins and long-term incident dementia. We included 1321 participants from the Three-City Study who completed a 24 h dietary recall, were free of dementia at the time of diet assessment, and were followed for an average of 7.4 years. In Cox proportional hazards models adjusted for multiple potential confounders, including overall diet quality, higher intake of folate was inversely associated with the risk of dementia (p for trend = 0.02), with an approximately 50% lower risk for individuals in the highest compared to the lowest quintile of folate (HR = 0.47; 95% CI 0.28; 0.81). No association was found for vitamins B6 and B12. In conclusion, in a large French cohort with a relatively low baseline folate status (average intake = 278 µg/day), higher folate intakes were associated with a decreased risk of dementia.
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DOI：
10.1016/j.jalz.2005.06.001
发表时间：
2005-07-01
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
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作者：
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影响因子：
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影响因子：
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影响因子：
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作者：
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影响因子：
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作者：
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