Green Nanotechnology from Tea: Phytochemicals in Tea as Building Blocks for Production of Biocompatible Gold Nanoparticles.
Green Nanotechnology from Tea: Phytochemicals in Tea as Building Blocks for Production of Biocompatible Gold Nanoparticles.
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DOI：
10.1039/b822015h
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发表时间：
2009-06-01
影响因子：
--
通讯作者：
Katti KV
中科院分区：
文献类型：
--
作者：
Nune SK;Chanda N;Shukla R;Katti K;Kulkarni RR;Thilakavathi S;Mekapothula S;Kannan R;Katti KV
茶叶中含有的植物化学物质已广泛用作膳食补充剂和天然药物，用于治疗包括人类癌症在内的各种疾病。本文介绍了茶叶中植物化学物质将金盐还原为相应金纳米颗粒的还原能力的结果。茶叶中存在的植物化学物质具有双重作用，既可以作为有效的还原剂来还原金，也可以作为稳定剂，在一步中为金纳米粒子提供坚固的涂层。茶生成的金纳米颗粒 (T-AuNP) 在各种缓冲液（包括盐水、组氨酸、HSA 和半胱氨酸溶液）中表现出显着的体外稳定性。具有植物化学涂层的 T-AuNP 对前列腺 (PC-3) 和乳腺癌 (MCF-7) 癌细胞表现出显着的亲和力。展示了 T-AuNP 通过胞吞作用进入 PC-3 和 MCF-7 细胞的细胞内化结果。 T-AuNP 的生成遵循绿色化学的所有原理，并且通过 MTT 测定评估发现其无毒。除了金盐之外，这种真正的生物绿色纳米技术过程中不使用任何“人造”化学品，从而为其在分子成像和治疗中的应用铺平了绝佳的机会。
Phytochemicals occluded in tea have been extensively used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases including human cancer. Results on the reduction capabilities of phytochemicals present in tea to reduce gold salts to the corresponding gold nanoparticles are presented in this paper. The phytochemicals present in tea serve the dual roles as effective reducing agents to reduce gold and also as stabilizers to provide robust coating on the gold nanoparticles in a single step. The Tea-generated gold nanoparticles (T-AuNPs), have demonstrated remarkable in vitro stability in various buffers including saline, histidine, HSA, and cysteine solutions. T-AuNPs with phytochemical coatings have shown significant affinity toward prostate (PC-3) and breast (MCF-7) cancer cells. Results on the cellular internalization of T-AuNPs through endocytosis into the PC-3 and MCF-7 cells are presented. The generation of T-AuNPs follows all principles of green chemistry and have been found to be non toxic as assessed through MTT assays. No ‘man made’ chemicals, other than gold salts, are used in this true biogenic green nanotechnological process thus paving excellent opportunities for their applications in molecular imaging and therapy.
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影响因子：
--
作者：
Ankamwar, B;Damle, C;Sastry, M
通讯作者：
Sastry, M
影响因子：
5.3
作者：
Benhar, M;Dalyot, I;Levitzki, A
通讯作者：
Levitzki, A
影响因子：
5.5
作者：
Han, Gang;Ghosh, Partha;Rotello, Vincent M.
通讯作者：
Rotello, Vincent M.
DOI：
10.1111/j.1440-1681.2006.04450.x
发表时间：
2006-09-01
影响因子：
2.9
作者：
Hodgson, J. M.
通讯作者：
Hodgson, J. M.
影响因子：
4.7
作者：
Gole, A;Dash, C;Sastry, M
通讯作者：
Sastry, M