High preoperative white blood cell count determines poor prognosis and is associated with an immunosuppressive microenvironment in colorectal cancer.
High preoperative white blood cell count determines poor prognosis and is associated with an immunosuppressive microenvironment in colorectal cancer.
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DOI：
10.3389/fonc.2022.943423
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发表时间：
2022
影响因子：
4.7
通讯作者：
Miao, Changhong
中科院分区：
文献类型：
--
作者：
Weng, Meilin;Zhao, Wenling;Yue, Ying;Guo, Miaomiao;Nan, Ke;Liao, Qingwu;Sun, Minli;Zhou, Di;Miao, Changhong
关键词：
高白色血细胞（WBC）计数和预后不良之间的相关性已被确定在各种类型的癌症;然而，白细胞计数在结直肠癌中的临床意义和免疫背景仍不清楚。2009年2月至2014年11月期间，上海市肿瘤防治中心7,433例择期结直肠癌手术患者入组本回顾性队列研究。将患者分为两组：术前低WBC组和术前高WBC组。倾向评分匹配用于解决基线特征的差异。采用Kaplan-Meier法和考克斯回归分析确定影响结直肠癌患者预后的独立因素。采用免疫组化染色法比较术前高、低WBC组肿瘤浸润免疫细胞。在接受结直肠癌手术并可用于分析的7，433例患者中，5，750例被纳入术前低WBC组，1，683例被纳入术前高WBC组。在倾向评分匹配后，每组包括1，553名患者。Kaplan-Meier生存曲线显示术前高WBC计数与总生存率下降相关（P = 0.002）和无病生存期（P = 0.003），术前白细胞计数是总生存率的独立危险因素（风险比，1.234; 95%可信区间，1.068-1.426; P = 0.004）和无病生存期（风险比，1.210; 95%可信区间，1.047-1.397，P = 0.01）。与术前低白细胞组相比，术前高白细胞组调节性T细胞的表达更高（P = 0.0034），CD 68+巨噬细胞（P = 0.0071）和CD 66 b+中性粒细胞（P = 0.0041）;程序性细胞死亡蛋白1表达增加（P = 0.005）和程序性细胞死亡配体1（P = 0.0019）;结直肠癌患者CD 8 + T细胞表达较低（P = 0.0057）。我们的研究表明，术前高WBC计数是结直肠癌患者的预后指标，并与免疫抑制肿瘤微环境相关，这可能有助于未来的风险分层。
The correlation between high white blood cell (WBC) count and poor prognosis has been identified in various types of cancer; however, the clinical significance and immune context of WBC count in colorectal cancer remains unclear. Between February 2009 and November 2014, 7,433 patients at the Shanghai Cancer Center who had undergone elective surgery for colorectal cancer were enrolled in this retrospective cohort study. Patients were divided into two groups: low and high preoperative WBC groups. Propensity score matching was used to address the differences in baseline characteristics. The Kaplan–Meier method and Cox regression analysis were used to identify independent prognostic factors in colorectal cancer patients. Tumor-infiltrating immune cells in the high and low preoperative WBC groups were compared using immunohistochemical staining. Of the 7,433 patients who underwent colorectal cancer surgery and were available for analysis, 5,750 were included in the low preoperative WBC group, and 1,683 were included in the high preoperative WBC group. After propensity score matching, 1,553 patients were included in each group. Kaplan–Meier survival curves showed that a high preoperative WBC count was associated with a decreased overall survival (P = 0.002) and disease-free survival (P = 0.003), and that preoperative WBC count was an independent risk factor for overall survival (hazard ratio, 1.234; 95% confidence interval, 1.068–1.426; P = 0.004) and disease-free survival (hazard ratio, 1.210; 95% confidence interval, 1.047–1.397, P = 0.01). Compared to the low preoperative WBC group, the high preoperative WBC group exhibited higher expression of regulatory T cells (P = 0.0034), CD68+ macrophages (P = 0.0071), and CD66b+ neutrophils (P = 0.0041); increased expression of programmed cell death protein 1 (P = 0.005) and programmed cell death ligand 1 (P = 0.0019); and lower expression of CD8+ T cells (P = 0.0057) in colorectal cancer patients. Our research indicates that a high preoperative WBC count is a prognostic indicator in colorectal cancer patients and is associated with an immunosuppressive tumor microenvironment, which could aid in future risk stratification.
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影响因子：
10.5
作者：
Brennan CA;Garrett WS
通讯作者：
Garrett WS
影响因子：
5.2
作者：
de Nonneville, Alexandre;Barbolosi, Dominique;Salas, Sebastien
通讯作者：
Salas, Sebastien
影响因子：
2.2
作者：
Li R;Liu H;Dilger JP;Lin J
通讯作者：
Lin J
DOI：
10.1158/1078-0432.ccr-17-1323
发表时间：
2018-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Afghahi A;Purington N;Han SS;Desai M;Pierson E;Mathur MB;Seto T;Thompson CA;Rigdon J;Telli ML;Badve SS;Curtis CN;West RB;Horst K;Gomez SL;Ford JM;Sledge GW;Kurian AW
通讯作者：
Kurian AW
影响因子：
11.2
作者：
Chang, Li-Yuan;Lin, Yung-Chang;Lin, Chun-Yen
通讯作者：
Lin, Chun-Yen