A structural and functional subdivision in central orbitofrontal cortex.
A structural and functional subdivision in central orbitofrontal cortex.
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DOI：
10.1038/s41467-022-31273-9
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发表时间：
2022-06-24
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
经济选择需要许多认知子过程，包括刺激检测、评估、运动输出和结果监控；许多这些子过程都与中央眶额皮层（cOFC）相关。先前的工作很大程度上假设 cOFC 是具有单一功能的单一区域。在这里，我们用恒河猴的趋同的解剖学和生理学结果挑战了这一统一观点。在解剖学上，我们表明，cOFC 可以根据其与后扣带皮层 (PCC) 的双向解剖连接性强得多（内侧）或多弱（外侧）进行细分。我们分别将这些子区域称为 cOFCm 和 cOFCl。这两个次区域具有显着的功能差异。具体来说，cOFCm 显示出与 PCC 增强的功能连接，如尖峰场相干性和互信息所示。 cOFCm-PCC电路，而不是cOFC1-PCC电路，显示了将选择信号从非空间比较框架中继到空间框架组织的特征，并显示了假定的双向相互兴奋模式。眶额皮层的一部分可以根据其与后扣带皮层的连接性进行细分。这种基于连通性的分割显示了功能连通性和经济选择信号的差异。
Economic choice requires many cognitive subprocesses, including stimulus detection, valuation, motor output, and outcome monitoring; many of these subprocesses are associated with the central orbitofrontal cortex (cOFC). Prior work has largely assumed that the cOFC is a single region with a single function. Here, we challenge that unified view with convergent anatomical and physiological results from rhesus macaques. Anatomically, we show that the cOFC can be subdivided according to its much stronger (medial) or weaker (lateral) bidirectional anatomical connectivity with the posterior cingulate cortex (PCC). We call these subregions cOFCm and cOFCl, respectively. These two subregions have notable functional differences. Specifically, cOFCm shows enhanced functional connectivity with PCC, as indicated by both spike-field coherence and mutual information. The cOFCm-PCC circuit, but not the cOFCl-PCC circuit, shows signatures of relaying choice signals from a non-spatial comparison framework to a spatially framed organization and shows a putative bidirectional mutually excitatory pattern. A portion of the orbitofrontal cortex can be subdivided by its connectivity with the posterior cingulate cortex. This connectivity-based parcellation shows differences in functional connectivity and economic choice signals.
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影响因子：
16.2
作者：
Bartolo, Ramon;Averbeck, Bruno B.
通讯作者：
Averbeck, Bruno B.
DOI：
10.3758/bf03195489
发表时间：
2002-11-01
期刊：
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS
影响因子：
--
作者：
Cornelissen, FW;Peters, EM;Palmer, J
通讯作者：
Palmer, J
影响因子：
16.2
作者：
Cai X;Padoa-Schioppa C
通讯作者：
Padoa-Schioppa C
影响因子：
3
作者：
Bokil, Hemant;Andrews, Peter;Kulkarni, Jayant E.;Mehta, Samar;Mitra, Partha P.
通讯作者：
Mitra, Partha P.
影响因子：
5
作者：
Heilbronner SR
通讯作者：
Heilbronner SR