The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy.
The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy.
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DOI：
10.1016/j.jdiacomp.2012.05.007
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发表时间：
2012-09
影响因子：
3
通讯作者：
Wright DE
中科院分区：
文献类型：
--
作者：
Kluding PM;Pasnoor M;Singh R;Jernigan S;Farmer K;Rucker J;Sharma NK;Wright DE
尽管运动可以显着降低糖尿病并发症的患病率和严重程度，但尚无研究评估运动对诊断为糖尿病周围神经病变（DPN）患者神经功能的影响。这项试点研究的目的是检验 DPN 患者接受监督的中等强度有氧运动和抗阻运动计划的可行性和有效性。我们假设运动干预可以改善神经病理症状、神经功能和皮肤神经支配。测试前测试后设计旨在评估参加为期 10 周的有氧运动和强化运动计划后结果指标的变化。 17 名诊断为 DPN 的受试者（8 名男性/9 名女性；年龄 58.4±5.98；糖尿病病程 12.4±12.2 年）完成了研究。结果测量包括疼痛测量（视觉模拟量表）、密歇根神经病变筛查仪（MNSI）神经病变症状问卷、神经功能测量以及远端和近端下肢皮肤活检中的表皮内神经纤维（IENF）密度和分支。干预后，近端皮肤活检显示疼痛显着减轻（100毫米尺度上为-18.1±35.5毫米，p=0.05）、神经性症状（MNSI上为-1.24±1.8，p=0.01）以及表皮内神经纤维分支增加（+0.11±0.15分支节点/纤维，p=-.008）。这是第一项描述糖尿病周围神经病变患者在监督运动后神经病变和皮肤神经纤维分支改善的研究。鉴于干预持续时间短，这些发现特别有希望，但需要在未来的研究中通过与对照组进行比较来验证。
Although exercise can significantly reduce the prevalence and severity of diabetic complications, no studies have evaluated the impact of exercise on nerve function in people with diagnosed diabetic peripheral neuropathy (DPN). The purpose of this pilot study was to examine feasibility and effectiveness of a supervised, moderately intense aerobic and resistance exercise program in people with DPN. We hypothesize that the exercise intervention can improve neuropathic symptoms, nerve function, and cutaneous innervation. A pre-test post-test design was to assess change in outcome measures following participation in a 10-week aerobic and strengthening exercise program. Seventeen subjects with diagnosed DPN (8 males/9 females; age 58.4±5.98; duration of diabetes 12.4±12.2 years) completed the study. Outcome measures included pain measures (visual analog scale), Michigan Neuropathy Screening Instrument (MNSI) questionnaire of neuropathic symptoms, nerve function measures, and intraepidermal nerve fiber (IENF) density and branching in distal and proximal lower extremity skin biopsies. Significant reductions in pain (−18.1±35.5 mm on a 100 mm scale, p=0.05), neuropathic symptoms (−1.24±1.8 on MNSI, p=0.01), and increased intraepidermal nerve fiber branching (+0.11±0.15 branch nodes/fiber, p=−.008) from a proximal skin biopsy were noted following the intervention. This is the first study to describe improvements in neuropathic and cutaneous nerve fiber branching following supervised exercise in people with diabetic peripheral neuropathy. These findings are particularly promising given the short duration of the intervention, but need to be validated by comparison with a control group in future studies.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
--
作者：
Davidson, Lance E.;Hudson, Robert;Ross, Robert
通讯作者：
Ross, Robert
影响因子：
3
作者：
Balducci, Stefano;Iacobellis, Gianluca;Fallucca, Francesco
通讯作者：
Fallucca, Francesco
影响因子：
8
作者：
Dyck, Peter J.;Albers, James W.;Russell, James W.
通讯作者：
Russell, James W.
DOI：
10.1249/mss.0b013e3181d322dd
发表时间：
2010-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Larose, Joanie;Sigal, Ronald J.;Kenny, Glen P.
通讯作者：
Kenny, Glen P.