Is promiscuity associated with enhanced selection on MHC-DQα in mice (genus Peromyscus)?
Is promiscuity associated with enhanced selection on MHC-DQα in mice (genus Peromyscus)?
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DOI：
10.1371/journal.pone.0037562
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lacey EA
中科院分区：
文献类型：
--
作者：
MacManes MD;Lacey EA
生殖行为可能在主要组织相容性复合体（MHC）基因的选择中起重要作用。例如，一个人拥有的性伴侣的数量可能会影响对性传播病原体的暴露，更多的伴侣会导致更大的暴露，因此，可能会对MHC基因座的变异产生更大的选择。为了探讨这一假说，我们检查了两种Peromyscus MHC-DQα基因座外显子2的选择强度。虽然加州小鼠（P. californicus）的特点是终身社会和遗传一夫一妻制，鹿鼠（P. maniculatus）是社会和遗传混杂;与这些交配行为的差异一致，雌性生殖道内存在的细菌多样性显着更大的P. maniculatus。为了验证更多的生殖伴侣和暴露于更大范围的性传播病原体与负责免疫功能的基因的增强多样性选择相关的预测，我们比较了同域种群的P. maniculatus和P. californicus中II类MHC-DQα基因座的多样性模式和水平。使用基于可能性的分析，我们表明，在混杂P. maniculatus的选择增强。这项研究是第一次比较选择在野生同域啮齿动物与已知的病原体环境的差异的强度。
Reproductive behavior may play an important role in shaping selection on Major Histocompatibility Complex (MHC) genes. For example, the number of sexual partners that an individual has may affect exposure to sexually transmitted pathogens, with more partners leading to greater exposure and, hence, potentially greater selection for variation at MHC loci. To explore this hypothesis, we examined the strength of selection on exon 2 of the MHC-DQα locus in two species of Peromyscus. While the California mouse (P. californicus) is characterized by lifetime social and genetic monogamy, the deer mouse (P. maniculatus) is socially and genetically promiscuous; consistent with these differences in mating behavior, the diversity of bacteria present within the reproductive tracts of females is significantly greater for P. maniculatus. To test the prediction that more reproductive partners and exposure to a greater range of sexually transmitted pathogens are associated with enhanced diversifying selection on genes responsible for immune function, we compared patterns and levels of diversity at the Class II MHC-DQα locus in sympatric populations of P. maniculatus and P. californicus. Using likelihood based analyses, we show that selection is enhanced in the promiscuous P. maniculatus. This study is the first to compare the strength of selection in wild sympatric rodents with known differences in pathogen milieu.
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