Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease.
Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease.
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DOI：
10.1371/journal.pone.0090814
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hornberger M
中科院分区：
文献类型：
--
作者：
Frings L;Yew B;Flanagan E;Lam BY;Hüll M;Huppertz HJ;Hodges JR;Hornberger M
行为变异性额颞叶痴呆（bvFTD）和阿尔茨海默病（AD）痴呆的特点是进行性脑萎缩。纵向 MRI 容积测量可能有助于表征持续的结构退化并支持痴呆亚型的鉴别诊断。应用自动化、独立于观察者的基于图集的 MRI 容积法来分析来自 15 位 bvFTD、14 位 AD 和 10 位健康老年对照参与者的 102 个 MRI 数据集，这些参与者在至少 12 个月内连续扫描。先验地选择解剖学上定义的目标作为感兴趣的大脑结构。比较各组的临床表现体积和年度变化率。 bvFTD 和 AD 患者的基线体积，尤其是灰质区室的基线体积显着减少。 bvFTD 中尾状核和直回的灰质体积明显小于 AD。 bvFTD 组可以根据尾状核体积以高精度（79% 的病例正确）将 bvFTD 组与 AD 区分开。 bvFTD 和 AD 中的年体积下降明显大于对照组，主要是颞结构的白质。将 bvFTD 与 AD 和对照组分开的眶额外侧回灰质体积下降。自动纵向 MRI 容积测定可区分 bvFTD 和 AD。特别是，12 个月后眶额灰质和颞叶白质结构的更大减少表明 bvFTD。
Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, observer-independent atlas-based MRI volumetry was applied to analyse 102 MRI data sets from 15 bvFTD, 14 AD, and 10 healthy elderly control participants with consecutive scans over at least 12 months. Anatomically defined targets were chosen a priori as brain structures of interest. Groups were compared regarding volumes at clinic presentation and annual change rates. Baseline volumes, especially of grey matter compartments, were significantly reduced in bvFTD and AD patients. Grey matter volumes of the caudate and the gyrus rectus were significantly smaller in bvFTD than AD. The bvFTD group could be separated from AD on the basis of caudate volume with high accuracy (79% cases correct). Annual volume decline was markedly larger in bvFTD and AD than controls, predominantly in white matter of temporal structures. Decline in grey matter volume of the lateral orbitofrontal gyrus separated bvFTD from AD and controls. Automated longitudinal MRI volumetry discriminates bvFTD from AD. In particular, greater reduction of orbitofrontal grey matter and temporal white matter structures after 12 months is indicative of bvFTD.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
4.2
作者：
Dalton, Marshall A.;Weickert, Thomas W.;Hornberger, Michael
通讯作者：
Hornberger, Michael
影响因子：
4.8
作者：
Frings, Lars;Mader, Irina;Huppertz, Hans-Juergen
通讯作者：
Huppertz, Hans-Juergen
影响因子：
3.7
作者：
Lillo P;Mioshi E;Burrell JR;Kiernan MC;Hodges JR;Hornberger M
通讯作者：
Hornberger M
影响因子：
14.5
作者：
Hornberger, Michael;Wong, Stephanie;Halliday, Glenda
通讯作者：
Halliday, Glenda