The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals.
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals.
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DOI：
10.1093/cercor/bhn113
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发表时间：
2009-03
期刊：
影响因子：
3.7
通讯作者：
Buckner, Randy L.
中科院分区：
文献类型：
--
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
关键词：
阿尔茨海默氏病（AD）与大脑皮层的脆弱边缘和异源区域中的神经退行性区域有关，可以使用磁共振成像在体内检测到，尚不清楚AD中的皮质解剖学异常是否可以在不同的受试者中可靠地测量。它们跟踪症状，是否可以在症状之前检测到探索性的探索性稀疏图，用于定义以假设驱动的方式应用于其他受试者样本的感兴趣区域。 AD中的皮质解剖学异常的特征，在脆弱的皮质区域中，已知的区域脆弱性与症状严重程度有关通过淀粉样蛋白成像检测到与广告相关的皮质变薄的可靠性和临床有效性，表明潜在的效用作为成像生物标志物。对于假设驱动的分析，可以为神经精神疾病的研究提供有力的方法论框架。
Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities of cortical anatomy in AD can be reliably measured across different subject samples, how closely they track symptoms, and whether they are detectable prior to symptoms. An exploratory map of cortical thinning in mild AD was used to define regions of interest that were applied in a hypothesis-driven fashion to other subject samples. Results demonstrate a reliably quantifiable in vivo signature of abnormal cortical anatomy in AD, which parallels known regional vulnerability to AD neuropathology. Thinning in vulnerable cortical regions relates to symptom severity even in the earliest stages of clinical symptoms. Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging. The reliability and clinical validity of AD-related cortical thinning suggests potential utility as an imaging biomarker. This “disease signature” approach to cortical morphometry, in which disease effects are mapped across the cortical mantle and then used to define ROIs for hypothesis-driven analyses, may provide a powerful methodological framework for studies of neuropsychiatric diseases.
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