Inhalation injury in severely burned children does not augment the systemic inflammatory response.
Inhalation injury in severely burned children does not augment the systemic inflammatory response.
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DOI：
10.1186/cc5698
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发表时间：
2007
期刊：
影响因子：
15.1
通讯作者：
Jeschke, Marc G.
中科院分区：
文献类型：
--
作者：
Finnerty, Celeste C.;Herndon, David N.;Jeschke, Marc G.
吸入性损伤与严重的热损伤相结合会增加死亡率。炎症介质（例如细胞因子）的改变会导致多器官衰竭和死亡的发生。本研究的目的是确定吸入性损伤对严重烧伤儿童细胞因子表达的影响。 30 名患有吸入性损伤的严重烧伤儿童患者和 42 名没有吸入性损伤的严重烧伤儿童纳入了该研究。第一次手术时通过支气管镜检查诊断出吸入性损伤。入院后 24 小时内采集血液，并在入院后 5 至 7 天再次采集血液。使用多重抗体包被的珠子分析细胞因子表达。 p 值小于 0.05 时接受显着性。吸入性损伤组的全身表面积烧伤平均百分比为 67% ± 4%（56% ± 6%，三度烧伤），非吸入性损伤组为 60% ± 3%（45% ± 3%，三度烧伤）（p 值不显着 [NS]）。吸入性损伤组的平均年龄为 9 ± 1 岁，非吸入性损伤组的平均年龄为 8 ± 1 岁（p 值 NS）。吸入性损伤组从烧伤到入院的时间为 2 ± 1 天，而非吸入性损伤组为 3 ± 1 天（p 值 NS）。吸入性损伤组的死亡率为 40%，非吸入性损伤组的死亡率为 12% (p < 0.05)。入院时，与非吸入性损伤组相比，非吸入性损伤组血清白细胞介素（IL）-7显着升高，而吸入性损伤组IL-12p70显着升高（p < 0.05）。组间没有其他显着差异。入院后 5 至 7 天，所有细胞因子均下降，吸入性损伤组和非吸入性损伤组之间没有差异。在本研究中，我们表明吸入性损伤会导致 IL-7 和 IL-12p70 发生变化。促炎细胞因子水平没有增加，表明除了烧伤外，吸入性损伤不会增强烧伤后早期的全身炎症反应。
Inhalation injury in combination with a severe thermal injury increases mortality. Alterations in inflammatory mediators, such as cytokines, contribute to the incidence of multi-organ failure and mortality. The aim of the present study was to determine the effect of inhalation injury on cytokine expression in severely burned children. Thirty severely burned pediatric patients with inhalation injury and 42 severely burned children without inhalation injury were enrolled in the study. Inhalation injury was diagnosed by bronchoscopy during the first operation. Blood was collected within 24 hours of admission and again at five to seven days following admission. Cytokine expression was profiled using multi-plex antibody-coated beads. Significance was accepted at a p value of less than 0.05. The mean percentages of total body surface area burned were 67% ± 4% (56% ± 6%, third-degree burns) in the inhalation injury group and 60% ± 3% (45% ± 3%, third-degree burns) in the non-inhalation injury group (p value not significant [NS]). Mean age was 9 ± 1 years in the inhalation injury group and 8 ± 1 years in the non-inhalation injury group (p value NS). Time from burn to admission in the inhalation injury group was 2 ± 1 days compared to 3 ± 1 days in the non-inhalation injury group (p value NS). Mortalities were 40% in the inhalation injury group and 12% in the non-inhalation injury group (p < 0.05). At the time of admission, serum interleukin (IL)-7 was significantly increased in the non-inhalation injury group, whereas IL-12p70 was significantly increased in the inhalation injury group compared to the non-inhalation injury group (p < 0.05). There were no other significant differences between groups. Five to seven days following admission, all cytokines decreased with no differences between the inhalation injury and non-inhalation injury cohorts. In the present study, we show that an inhalation injury causes alterations in IL-7 and IL-12p70. There were no increased levels of pro-inflammatory cytokines, indicating that an inhalation injury in addition to a burn injury does not augment the systemic inflammatory response early after burn.
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影响因子：
3.1
作者：
Finnerty, Celeste C.;Herndon, David N.;Jeschke, Marc G.
通讯作者：
Jeschke, Marc G.
影响因子：
3.3
作者：
Hales, CA;Elsasser, TH;Efimova, O
通讯作者：
Efimova, O
影响因子：
2.7
作者：
Yeh, FL;Shen, HD;Fang, RH
通讯作者：
Fang, RH
影响因子：
9
作者：
CIOFFI, WG;DELEMOS, RA;PRUITT, BA
通讯作者：
PRUITT, BA
影响因子：
9
作者：
DROST, AC;BURLESON, DG;PRUITT, BA
通讯作者：
PRUITT, BA