A combined index of structure and function for staging glaucomatous damage.
A combined index of structure and function for staging glaucomatous damage.
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DOI：
10.1001/archophthalmol.2012.827
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发表时间：
2012-09
影响因子：
--
通讯作者：
Zangwill, Linda M.
中科院分区：
文献类型：
--
作者：
Medeiros, Felipe A.;Lisboa, Renato;Weinreb, Robert N.;Girkin, Christopher A.;Liebmann, Jeffrey M.;Zangwill, Linda M.
提出并评价一种新的青光眼损伤分期与检测的结构与功能联合指标。观察性研究包括333只青光眼（周围性青光眼295只，周围性青光眼38只）和330只健康人的眼睛。6个月内用标准自动视距仪（SAP）和光谱域光学相干层析成像（SDOCT）检测所有眼睛。通过SAP和SDOCT获得视网膜神经节细胞（RGC）数量的估计，并使用加权平均方案获得每只眼睛RGC数量的最终估计。CSFI的计算方法是用预期的RGC数量减去估计的RGC损失的百分比。通过受试者工作特征（ROC）曲线评估CSFI在区分青光眼与正常眼以及不同疾病阶段方面的表现。在围术期组和预围术期组中，代表RGCs平均估计损失百分比的平均CSFI分别为41%和17% （P<0.001）。两者均显著高于正常组CSFI平均值（P<0.001）。CSFI比孤立的结构和功能指标具有更大的ROC曲线面积，用于检测周边和准周边青光眼以及区分早、中、晚期视野丧失。结合结构和功能的指标比孤立的结构和功能指标更能检测出周边和准周边青光眼以及区分不同阶段的青光眼。
To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage. Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects. All eyes were tested with standard automated perimetry (SAP) and spectral domain optical coherence tomography (SDOCT) within 6 months. Estimates of the number of retinal ganglion cells (RGC) were obtained from SAP and SDOCT and a weighted averaging scheme was used to obtain a final estimate of the number of RGCs for each eye. The CSFI was calculated as the percent loss of RGCs obtained by subtracting estimated from expected RGC numbers. The performance of the CSFI for discriminating glaucoma from normal eyes and the different stages of disease was evaluated by receiver operating characteristic (ROC) curves The mean CSFI, representing the mean estimated percent loss of RGCs, was 41% and 17% in the perimetric and pre-perimetric groups, respectively (P<0.001). They were both significantly higher than the mean CSFI in the normal group (P<0.001). The CSFI had larger ROC curve areas than isolated indexes of structure and function for detecting perimetric and preperimetric glaucoma and differentiating among early, moderate and advanced stages of visual field loss. An index combining structure and function performed better than isolated structural and functional measures for detection of perimetric and preperimetric glaucoma as well as for discriminating different stages of the disease.
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影响因子：
4.4
作者：
Medeiros FA;Zangwill LM;Alencar LM;Bowd C;Sample PA;Susanna R Jr;Weinreb RN
通讯作者：
Weinreb RN
影响因子：
4.2
作者：
Medeiros, FA;Zangwill, LM;Weinreb, RN
通讯作者：
Weinreb, RN
影响因子：
--
作者：
Medeiros, Felipe A.;Alencar, Luciana M.;Zangwill, Linda M.;Bowd, Christopher;Sample, Pamela A.;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.
影响因子：
4.2
作者：
QUIGLEY, HA;DUNKELBERGER, GR;GREEN, WR
通讯作者：
GREEN, WR
影响因子：
13.7
作者：
Medeiros, Felipe A.;Vizzeri, Gianmarco;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.