XRCC3 C18067T polymorphism contributes a decreased risk to both basal cell carcinoma and squamous cell carcinoma: evidence from a meta-analysis.
XRCC3 C18067T polymorphism contributes a decreased risk to both basal cell carcinoma and squamous cell carcinoma: evidence from a meta-analysis.
复制标题
DOI：
10.1371/journal.pone.0084195
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Mo W
中科院分区：
文献类型：
--
作者：
Chen X;Wang Z;Yan Y;Li P;Yang Z;Qin L;Mo W
同源重组修复（HRR）途径中的X射线修复交叉互补组3（XRCC 3）在DNA双链断裂修复（DSBR）中起着非常重要的作用。XRCC 3基因的变异可能会导致蛋白质结构或功能的改变，从而改变DSBR的效率并导致癌症。XRCC 3 C18067 T多态性与皮肤癌易感性相关，但这些先前的结果不一致或有争议。为了更精确地估计这种关联，我们进行了荟萃分析。根据预先确定的量表评估研究质量。通过比值比（OR）及其95%置信区间（CI）评估XRCC 3 C18067 T多态性与皮肤癌风险之间的关联。总体而言，在任何遗传模型中，XRCC 3 C18067 T多态性与皮肤癌风险之间均未观察到显著相关性。按肿瘤类型分层分析，发现XRCC 3 C18067 T多态性与非黑色素瘤皮肤癌风险显著相关（纯合子比较TT与CC：OR = 0.74，95%CI = 0.61-0.90，P = 0.003;隐性模型TT与TC/CC：OR = 0.81，95%CI = 0.68-0.95，P = 0.01）。 此外，还观察到XRCC 3 C18067 T多态性与基底细胞癌风险显著相关（纯合子比较TT与CC：OR = 0.70，95%CI= 0.53-0.92，P = 0.011;隐性模型TT与CC：OR= 0.70，95%CI =0.53-0.92，P = 0.011）。 TC/CC：OR = 0.74，95%CI = 0.60-0.92，P = 0.007）和鳞状细胞癌风险（杂合子比较TT与.CC：OR = 0.81，95%CI = 0.67-0.99，P = 0.04;显性模型TT/TC与.CC：OR = 0.81，95%CI = 0.68-0.98，P = 0.029）。 目前的荟萃分析表明，XRCC 3 C18067 T多态性与皮肤黑色素瘤的风险无关，但有助于降低基底细胞癌和鳞状细胞癌的风险。
The X-ray repair cross-complementing group 3 (XRCC3) in homologous recombination repair (HRR) pathway plays a very important role in DNA double-strand break repair (DSBR). Variations in the XRCC3 gene might lead to altered protein structure or function which may change DSBR efficiency and result in cancer. The XRCC3 C18067T polymorphism has been reported to be associated with skin cancer susceptibility, yet the results of these previous results have been inconsistent or controversial. To derive a more precise estimation of the association, we conducted a meta-analysis. The quality of the studies was assessed according to a predefined scale. The association between the XRCC3 C18067T polymorphism and skin cancer risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Overall, no significant association was observed between XRCC3 C18067T polymorphism and skin cancer risk in any genetic model. Stratified analyses according to tumor type, significant association was found in the relationship between XRCC3 C18067T polymorphism and nonmelanoma skin cancer risk (homozygote comparison TT versus CC: OR = 0.74, 95%CI = 0.61–0.90, P = 0.003; recessive model TT versus TC/CC: OR = 0.81, 95%CI = 0.68–0.95, P = 0.01). Furthermore, significant association was also observed in XRCC3 C18067T polymorphism with both basal cell carcinoma risk (homozygote comparison TT versus CC: OR = 0.70, 95%CI = 0.53–0.92, P = 0.011; recessive model TT versus. TC/CC: OR = 0.74, 95%CI = 0.60–0.92, P = 0.007) and squamous cell carcinoma risk (heterozygote comparison TT versus .CC: OR = 0.81, 95%CI = 0.67–0.99, P = 0.04; dominant model TT/TC versus .CC: OR = 0.81, 95%CI = 0.68–0.98, P = 0.029). The present meta-analysis demonstrates that XRCC3 C18067T polymorphism was not associated with risk of cutaneous melanoma but contributed a decreased risk to both basal cell carcinoma and squamous cell carcinoma.
登录
查看更多内容
影响因子：
4.6
作者：
Goncalves, Fernanda T.;Francisco, Guilherme;Eluf-Neto, Jose
通讯作者：
Eluf-Neto, Jose
影响因子：
3.8
作者：
Han, JL;Hankinson, SE;De Vivo, I
通讯作者：
De Vivo, I
影响因子：
11.2
作者：
Han, JL;Colditz, GA;Hunter, DJ
通讯作者：
Hunter, DJ
影响因子：
5.2
作者：
Han, Shizhong;Zhang, Hong-Tao;Li, Yao
通讯作者：
Li, Yao
影响因子：
6.5
作者：
Jiang, De-Ke;Wang, Wen-Zhang;Yu, Long
通讯作者：
Yu, Long