Linking Stress, Catecholamine Autotoxicity, and Allostatic Load with Neurodegenerative Diseases: A Focused Review in Memory of Richard Kvetnansky.
Linking Stress, Catecholamine Autotoxicity, and Allostatic Load with Neurodegenerative Diseases: A Focused Review in Memory of Richard Kvetnansky.
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DOI：
10.1007/s10571-017-0497-x
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发表时间：
2018-01
影响因子：
4
通讯作者：
Kopin IJ
中科院分区：
文献类型：
--
作者：
Goldstein DS;Kopin IJ
在这篇重点综述中，我们提供了有关不断发展的概念的最新信息，这些概念可能将慢性压力和儿茶酚胺自毒性与帕金森病等神经退行性疾病联系起来。理查德·克韦特南斯基 (Richard Kvetnansky) 在压力和儿茶酚胺系统领域的贡献启发了本文提出的一些想法。我们提出，儿茶酚胺能系统的协调介导维持健康的调整，而这些系统与衰老相关的解体会导致调节障碍和帕金森病等神经退行性疾病。长期重复的与压力相关的儿茶酚胺释放和再摄取，以及随之而来的有毒多巴胺代谢物 3,4-二羟基苯乙醛形成的增加，可能会加速这一过程。
In this Focused Review we provide an update about evolving concepts that may link chronic stress and catecholamine autotoxicity with neurodegenerative diseases such as Parkinson’s disease. Richard Kvetnansky’s contributions to the field of stress and catecholamine systems inspired some of the ideas presented here. We propose that coordination of catecholaminergic systems mediates adjustments maintaining health and that senescence-related disintegration of these systems leads to disorders of regulation and to neurodegenerative diseases such as Parkinson’s disease. Chronically repeated episodes of stress-related catecholamine release and reuptake, with attendant increases in formation of the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde, might accelerate this process.
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影响因子：
10.4
作者：
Bronstein, Jeff;Carvey, Paul;Chen, Honglei;Cory-Slechta, Deborah;DiMonte, Donato;Duda, John;English, Paul;Goldman, Samuel;Grate, Stephen;Hansen, Johnni;Hoppin, Jane;Jewell, Sarah;Kamel, Freya;Koroshetz, Walter;Langston, James W.;Logroscino, Giancarlo;Nelson, Lorene;Ravina, Bernard;Rocca, Walter;Ross, George W.;Schettler, Ted;Schwarzschild, Michael;Scott, Bill;Seegal, Richard;Singleton, Andrew;Steenland, Kyle;Tanner, Caroline M.;Van Den Eeden, Stephen;Weisskopf, Marc
通讯作者：
Weisskopf, Marc
影响因子：
4.8
作者：
Follmer, Cristian;Coelho-Cerqueira, Eduardo;Eliezer, David
通讯作者：
Eliezer, David
影响因子：
12.6
作者：
Cai H;Liu G;Sun L;Ding J
通讯作者：
Ding J
影响因子：
4.1
作者：
Anderson, David G.;Florang, Virginia R.;Doorn, Jonathan A.
通讯作者：
Doorn, Jonathan A.
影响因子：
4.8
作者：
Bisaglia, Marco;Mammi, Stefano;Bubacco, Luigi
通讯作者：
Bubacco, Luigi