Presence of NF‐κB‐like and IκB‐like immunoreactivities in postsynaptic densities
Presence of NF‐κB‐like and IκB‐like immunoreactivities in postsynaptic densities
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突触后密度中存在 NF-κB 样和 IκB 样免疫反应性
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
T. Okamoto
中科院分区：
文献类型：
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作者：
Tatsuo Suzuki;S. Mitake;K. Okumura‐Noji;Jian;T. Fujii;T. Okamoto
用透射电镜观察IκB和NF-κB免疫反应阳性细胞在大鼠脑内的分布。针对具有对人MAD-3 IκB型或NF-κB型特异性的序列的合成肽产生抗体。IκBa和NF-κB免疫反应均位于树突，包括棘，尤其是海马和大脑皮质的突触后密度（PSD）。从大鼠脑制备的PSD组分含有抑制NF-κB与κB DNA元件结合的活性。这些结果提示NF-κB/IκB系统或类似机制可能在突触向核的信号传递中起作用。
THE distributions of IκB and NF-κB immunoreactivities were examined immunohistochemically in the rat brain by the electron microscopy. Antibodies were raised against synthetic peptides with the sequences specific to the human MAD-3 type IκB or NF-κB. Both IκBa and NF-κB immunoreactivities were localized in the dendrites including the spines and, particularly, the postsynaptic densities (PSDs) of the hippocampus and the cerebral cortex. The PSD fraction prepared from the rat brain contained an activity that inhibited the binding of NF-κB to the κB DNA elements. These results suggest that the NF-κB/IκB system or a similar mechanism may play a role in signal transmission from synapses to the nucleus.
DOI：
10.1073/pnas.90.20.9247
发表时间：
1993-10-15
影响因子：
11.1
作者：
LI, SF;SEDIVY, JM
通讯作者：
SEDIVY, JM
影响因子：
56.9
作者：
NGUYEN, PV;ABEL, T;KANDEL, ER
通讯作者：
KANDEL, ER