Extracellular vesicles: novel vehicles in herpesvirus infection.
Extracellular vesicles: novel vehicles in herpesvirus infection.
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细胞外囊泡：疱疹病毒感染的新载体
DOI：
10.1007/s12250-017-4073-9
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发表时间：
2017-10
影响因子：
5.5
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Liu L;Zhou Q;Xie Y;Zuo L;Zhu F;Lu J
疱疹病毒是一种引人注目的病原体，它进化出多种机制来逃避宿主的免疫，确保它们的增殖和扩散。在这些机制中，疱疹病毒利用复杂的胞外囊泡，包括外切体，在受感染的宿主和受体细胞之间复杂地相互作用。疱疹病毒将基因组表达产物和直接细胞产物合并到外体货物中。这些成分改变了供体细胞释放的外切体的内容和功能，从而影响了受体细胞的下游信号。通过这种方式，疱疹病毒劫持外体途径以确保其生存和持续，外体正在成为病毒感染相关细胞间通信和微环境改变的关键介质。本文就外切体在疱疹病毒感染中的作用和作用作一综述，以期对疱疹病毒的发病机制有更深入的了解。
Herpesviruses are remarkable pathogens that have evolved multiple mechanisms to evade host immunity, ensuring their proliferation and egress. Among these mechanisms, herpesviruses utilize elaborate extracellular vesicles, including exosomes, for the intricate interplay between infected host and recipient cells. Herpesviruses incorporate genome expression products and direct cellular products into exosomal cargoes. These components alter the content and function of exosomes released from donor cells, thus affecting the downstream signalings of recipient cells. In this way, herpesviruses hijack exosomal pathways to ensure their survival and persistence, and exosomes are emerging as critical mediators for virus infection-associated intercellular communication and microenvironment alteration. In this review, the function and effects of exosomes in herpesvirus infection will be discussed, so that we will have a better understanding about the pathogenesis of herpesviruses.
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