A homeostatic model of neuronal firing governed by feedback signals from the extracellular matrix.
A homeostatic model of neuronal firing governed by feedback signals from the extracellular matrix.
复制标题
DOI：
10.1371/journal.pone.0041646
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Dityatev A
中科院分区：
文献类型：
--
作者：
Kazantsev V;Gordleeva S;Stasenko S;Dityatev A
细胞外基质（ECM）分子可以调节突触传递和神经元兴奋性的功效。这些机制对于在延长的时间尺度上神经元放电的稳态调节至关重要。在这项研究中，我们介绍了一个简单的数学模型的神经元尖峰平衡的ECM的影响。我们考虑一个神经元接受随机突触输入的形式泊松尖峰列车和ECM，这是由一个现象学变量参与两个反馈机制。一种反馈机制缩放输入突触电导的值以补偿激发速率的变化。第二反馈说明了激励阈值的缓慢波动，并取决于ECM浓度。我们表明，ECM介导的反馈作为一个强大的机制，提供一个稳态的平均放电率的调整。有趣的是，反馈机制的激活可能会导致一个双稳态，其中两个不同的稳定水平的平均放电率可以共存于尖峰网络。我们讨论了双稳态的机制，以及它们如何可能与记忆功能。
Molecules of the extracellular matrix (ECM) can modulate the efficacy of synaptic transmission and neuronal excitability. These mechanisms are crucial for the homeostatic regulation of neuronal firing over extended timescales. In this study, we introduce a simple mathematical model of neuronal spiking balanced by the influence of the ECM. We consider a neuron receiving random synaptic input in the form of Poisson spike trains and the ECM, which is modeled by a phenomenological variable involved in two feedback mechanisms. One feedback mechanism scales the values of the input synaptic conductance to compensate for changes in firing rate. The second feedback accounts for slow fluctuations of the excitation threshold and depends on the ECM concentration. We show that the ECM-mediated feedback acts as a robust mechanism to provide a homeostatic adjustment of the average firing rate. Interestingly, the activation of feedback mechanisms may lead to a bistability in which two different stable levels of average firing rates can coexist in a spiking network. We discuss the mechanisms of the bistability and how they may be related to memory function.
登录
查看更多内容
影响因子：
5.6
作者：
Dityatev, Alexander
通讯作者：
Dityatev, Alexander
影响因子：
56.9
作者：
GAMBLE, E;KOCH, C
通讯作者：
KOCH, C
影响因子：
56.9
作者：
Beattie, EC;Stellwagen, D;Malenka, RC
通讯作者：
Malenka, RC
影响因子：
3
作者：
Dityatev, Alexander;Brueckner, Gert;Schachner, Melitta
通讯作者：
Schachner, Melitta
影响因子：
3
作者：
Wlodarczyk, Jakub;Mukhina, Irina;Dityatev, Alexander
通讯作者：
Dityatev, Alexander