FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling.
FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling.
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DOI：
10.1155/2018/7438608
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发表时间：
2018
影响因子：
4.1
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Tai H;Wu Z;Sun S;Zhang Z;Xu C
成纤维细胞生长因子受体样1(FGFRL1)是第五种成纤维细胞生长因子受体。到目前为止，人们对它的生物学功能知之甚少，特别是在癌症发展过程中。在这里，我们第一次展示了FGFRL1在卵巢癌(OC)中的作用。利用芯片和现有的数据库研究FGFRL1的表达谱以及FGFRL1的表达与临床病理参数的关系。卵巢癌组织中FGFRL1表达明显上调，且高表达与预后不良相关。通过体外细胞增殖、细胞凋亡和迁移实验，以及体内异种皮下移植瘤模型来确定FGFRL1的作用。FGFRL1功能缺失在体外显著影响OC细胞的增殖、凋亡和迁移，在体内影响肿瘤生长。用染色质免疫沉淀、聚合酶链式反应分析和微阵列杂交等方法揭示其作用机制。缺氧可通过低氧诱导因子1α直接与FGFRL1启动子元件结合而诱导FGFRL1的表达。FGFRL1通过与Hedgehog(HH)信号串扰促进肿瘤进展。综上所述，FGFRL1是一个潜在的预测因子，在肿瘤生长和HH信号转导中发挥重要作用，可能成为治疗OC的潜在靶点。
Fibroblast growth factor receptor-like-1 (FGFRL1) has been identified as the fifth fibroblast growth factor receptor. So far, little is known about its biological functions, particularly in cancer development. Here, for the first time, we demonstrated the roles of FGFRL1 in ovarian carcinoma (OC). An array and existing databases were used to investigate the expression profile of FGFRL1 and the relationship between FGFRL1 expression and clinicopathological parameters. FGFRL1 was significantly upregulated in OC patients, and high FGFRL1 expression was correlated with poor prognosis. In vitro cell proliferation, apoptosis and migration assays, and in vivo subcutaneous xenograft tumor models were used to determine the role of FGFRL1. Loss of function of FGFRL1 significantly influenced cell proliferation, apoptosis, and migration of OC cells in vitro and tumor growth in vivo. Chromatin immunoprecipitation PCR analysis and microarray hybridization were performed to uncover the mechanism. FGFRL1 expression could be induced by hypoxia through hypoxia-inducible factor 1α, which directly binds to the promoter elements of FGFRL1. FGFRL1 promoted tumor progression by crosstalk with Hedgehog (Hh) signaling. Taken together, FGFRL1 is a potential predictor and plays an important role in tumor growth and Hh signaling which could serve as potential therapeutic targets for the treatment of OC.
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影响因子：
3.7
作者：
Olbryt M;Habryka A;Student S;Jarząb M;Tyszkiewicz T;Lisowska KM
通讯作者：
Lisowska KM
影响因子：
2.9
作者：
Zhuang L;Steinberg F;Trueb B
通讯作者：
Trueb B
DOI：
10.1016/s0167-4781(00)00282-7
发表时间：
2001-03-19
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Kim, I;Moon, SO;Koh, GY
通讯作者：
Koh, GY
影响因子：
4.8
作者：
Trueb, B;Zhuang, L;Wiedemann, M
通讯作者：
Wiedemann, M
DOI：
10.1016/j.bbamcr.2015.05.027
发表时间：
2015-10-01
影响因子：
5.1
作者：
Zhuang, Lei;Pandey, Amit V.;Trueb, Beat
通讯作者：
Trueb, Beat