Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine-Induced Parkinsonism in Rats
Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine-Induced Parkinsonism in Rats
复制标题
短期膳食鱼油补充剂可改善与利血平诱发的大鼠帕金森病相关的运动缺陷
作者：
R. Barcelos;D. Benvegnú;N. Boufleur;C. Pase;A. Teixeira;P. Reckziegel;T. Emanuelli;J. Rocha;M. Bürger
鱼油（FO）补充剂可导致血浆游离脂肪酸浓度增加，因此，可与脑脊液中脑生物膜代谢产生的促炎性花生四烯酸（ARA）竞争。必需脂肪酸（EFA）（n-3）的抗氧化和神经保护性能已被报道，因此研究了FO补充对利血平诱导的运动障碍的影响。Wistar大鼠经口给予FO溶液5天，并与利血平（R; 1 mg/kg/mL）或其溶媒共给药3天（每隔一天）。FO能明显预防利血平诱发的口面运动障碍和僵住（P <0.05）。生化指标显示利血平处理增加了皮层和纹状体的脂质过氧化作用（P < 0.05），而FO补充则阻止了这两个脑区的氧化作用（P < 0.05）。我们的研究结果表明FO在脑脂质膜中的保护作用，加强了n-3脂肪酸在预防退行性疾病和运动障碍中的有益作用。
Fish oil (FO) supplementation could cause an increase in the concentration of plasmatic free fatty acids and, consequently, could compete with pro-inflammatory arachidonic acid (ARA) derived from brain biomembranes metabolism in the cerebrospinal fluid. Essential fatty acids (EFA) (n-3) have been reported by their antioxidant and neuroprotective properties, and therefore the influence of the FO supplementation on the reserpine-induced motor disorders was studied. Wistar rats were orally treated with FO solution for 5 days, and co-treated with reserpine (R; 1 mg/kg/mL) or its vehicle for 3 days (every other day). Reserpine-induced orofacial dyskinesia and catalepsy (P < 0.05) were prevented by FO (P < 0.05). Biochemical evaluations showed that reserpine treatment increased the lipid peroxidation in the cortex and striatum (P < 0.05), while the FO supplementation prevented this oxidative effect in both brain regions (P < 0.05). Our results showed the protective role of FO in the brain lipid membranes, reinforcing the beneficial effect of n-3 fatty acids in the prevention of degenerative and motor disorders.
影响因子：
4.2
作者：
Wu, A;Ying, Z;Gomez-Pinilla, F
通讯作者：
Gomez-Pinilla, F