Metal uptake in host-pathogen interactions: role of iron in Porphyromonas gingivalis interactions with host organisms.
Metal uptake in host-pathogen interactions: role of iron in Porphyromonas gingivalis interactions with host organisms.
复制标题
DOI：
10.1111/j.1600-0757.2009.00329.x
复制
发表时间：
2010-02
影响因子：
18.6
通讯作者：
Lewis JP
中科院分区：
文献类型：
--
作者：
Lewis JP
铁是几乎所有生物体生长所必需的营养素。病原生物在哺乳动物宿主中的毒力与铁的可利用性有关，因此，微生物铁获取机制是感染潜力的重要决定因素。事实上，铁水平调节存在于微生物基因组上的所有基因的10-20%，包括铁获得机制和毒力因子编码基因。铁与微生物毒力之间的关系已得到充分证实（121，158）。许多感染性疾病，如淋病、疟疾、结核病和疟疾感染，依赖于能够与宿主的铁清除机制竞争的微生物获得机制的表达。铁在哺乳动物宿主中的可用性极低，因此，成功的病原体进化出克服这一限制的策略。一些病原体产生能够与宿主的清除机制竞争的高亲和力金属螯合剂，而另一些病原体降解并释放哺乳动物蛋白质，如结合铁或氯化血红素的转铁蛋白或血红蛋白。遗传易感性、治疗干预或营养状况导致的宿主铁超载也可增加许多病原体感染的风险，如恶性疟原虫和结核分枝杆菌（121）。通过施用捕获游离铁并与获取系统竞争的铁螯合剂来治疗宿主可以限制微生物铁获取。然而，这种治疗也限制了宿主铁的可用性，这也可能产生破坏性影响。改变铁可用性的另一种方法是干扰病原体在感染的特定阶段生存所需的微生物铁获取机制。因此，了解细菌感染不同阶段铁获得机制的作用可能会导致其他干预策略的发展。口腔内至少有700种不同的细菌（1，19，104，105，139）。这些物种中的许多物种对口腔疾病的发病和进展的贡献仍有待确定。然而，几种细菌物种强烈暗示牙周病的病原体。其中包括拟杆菌门的成员：
Iron is a nutrient that is indispensable for growth of almost all living organisms. The virulence of pathogenic organisms in the mammalian host is related to the availability of iron, therefore, microbial iron acquisition mechanisms are an important determinant of infection potential. Indeed, iron levels regulate 10–20% of all genes present on microbial genomes, including iron acquisition mechanism and virulence factor encoding genes. The association between iron and microbial virulence is well established (121,158). Many infectious diseases, such as gonorrhea, malaria, tuberculosis, and diarrheal infections, depend on the expression of microbial acquisition mechanisms capable of competing with the host’s iron scavenging mechanisms. The availability of iron in the mammalian host is extremely low, therefore, successful pathogens evolved strategies to overcome this limitation. Some pathogens produce high affinity metal chelators capable of competing with the host’s scavenging mechanisms, while others degrade and release mammalian proteins such as transferrin or hemoglobin that bind iron or hemin. Iron overload in the host from genetic predispositions, therapeutic intervention, or nutritional status can also increase the risk of infection by many pathogens, such as Plasmodium falciparum and Mycobacterium tuberculosis (121). Treating the host by administering iron chelators that capture free iron and compete with the acquisition system can limit microbial iron acquisition. However, this treatment also limits the availability of iron for the host, which can also have a damaging effect. Another way to alter iron availability is to interfere with the microbial iron acquisition mechanisms required by the pathogen to survive at specific stages of infection. Therefore, understanding the role of the iron acquisition mechanisms at various stages of bacterial infection may lead to the development of additional interventional strategies.The oral cavity harbors at least 700 different species of bacteria (1, 19,104,105,139). The contribution of many of those species to onset and progression of oral diseases is still to be established. However, several bacterial species are strongly implicated as aetiological agents of periodontal diseases. Among them are members of the Bacteroidetes phylum:
登录
查看更多内容
影响因子：
6.7
作者：
Colombo, AP;Haffajee, AD;Socransky, SS
通讯作者：
Socransky, SS
影响因子：
3.1
作者：
Al-Qutub, Montaser N.;Braham, Pamela H.;Darveau, Richard P.
通讯作者：
Darveau, Richard P.
DOI：
10.1111/j.1432-1033.1974.tb03295.x
发表时间：
1974-01-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
BEAVEN, GH;CHEN, SH;GRATZER, WB
通讯作者：
GRATZER, WB
影响因子：
3.2
作者：
AduseOpoku, J;Slaney, JM;Curtis, MA
通讯作者：
Curtis, MA
影响因子：
3.2
作者：
Bainbridge, Brian W.;Karimi-Naser, Lisa;Darveau, Richard P.
通讯作者：
Darveau, Richard P.