Probing the phytopathogenic stem rot fungus with phytoalexins and analogues: unprecedented glucosylation of camalexin and 6-methoxycamalexin.
Probing the phytopathogenic stem rot fungus with phytoalexins and analogues: unprecedented glucosylation of camalexin and 6-methoxycamalexin.
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用植物抗毒素和类似物探索植物病原性茎腐真菌：camalexin 和 6-methoxycamalexin 的前所未有的糖基化。
DOI：
10.1016/s0968-0896(02)00208-0
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发表时间：
2002
影响因子：
3.5
通讯作者：
P. W. Ahiahonu
中科院分区：
文献类型：
--
作者：
M. Pedras;P. W. Ahiahonu
报道了十字花科植物抗毒素camalexin和6-甲氧基camalexin在茎腐病病原菌Sclerotinia sclerotiorum中的代谢。生物转化产生了在吲哚环的N-1或C-6处葡萄糖基化的camalexins，其抗真菌活性显著低于camalexins。N-1和C-6位被阻断的camalexin类似物被代谢，但速度比天然植物抗毒素慢得多。天然camalexins和两个新的类似物，以及它们的新代谢产物和各自的抗真菌活性的代谢所涉及的化学进行了描述。
The remarkable metabolism of the cruciferous phytoalexins camalexin and 6-methoxycamalexin by the stem rot phytopathogen Sclerotinia sclerotiorum is reported. The biotransformations yielded camalexins glucosylated at N-1 or C-6 of the indole ring, with substantially lower antifungal activity than camalexins. A camalexin analogue with the positions N-1 and C-6 blocked was metabolized but at a much slower rate than the natural phytoalexins. The chemistry involved in the metabolism of natural camalexins and two new analogues, as well as their novel metabolites and respective antifungal activities is described.
影响因子：
5.1
作者：
Chatterjee, P;Pezzuto, JM;Kouzi, SA
通讯作者：
Kouzi, SA