Chemokines and chemokine receptors as promoters of prostate cancer growth and progression.
Chemokines and chemokine receptors as promoters of prostate cancer growth and progression.
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DOI：
10.1615/critreveukaryotgeneexpr.2013006905
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发表时间：
2013
影响因子：
1.6
通讯作者：
Lokeshwar BL
中科院分区：
文献类型：
--
作者：
Salazar N;Castellan M;Shirodkar SS;Lokeshwar BL
前列腺癌(CAP)估计是癌症中发病率最高的，2012年美国新增病例超过24万例。趋化因子及其受体为肿瘤原发部位和转移部位的细胞提供存活、增殖和侵袭的特征。新的数据表明，许多趋化因子及其受体参与CAP的多步骤过程，导致转移，进一步，这些因素协同作用，促进肿瘤细胞生存、生长和转移的其他机制。趋化因子受体队列的改变可能是激活促肿瘤信号所必需的。趋化因子受体可以通过以下复杂机制激活下游效应器，如丝裂原激活的蛋白激酶：隐形生长因子的配体依赖激活；三磷酸鸟苷结合、存活激酶的蛋白偶联激活；或其他受体的反式激活，如ErbB家族成员。我们描述了先锋研究，在这些研究中，趋化因子受体生物学的经典观点得到了澄清。控制趋化因子和抑制其受体激活可能会增加减少肿瘤生长的关键工具，特别是在化疗激素难治性帽子中，这种帽子目前既是无法治愈的，也是最具侵袭性的疾病形式，占每年超过2.8万人死亡的大部分。
Prostate cancer (CaP) is estimated to be first in incidence among cancers, with more than 240,000 new cases in 2012 in the United States. Chemokines and their receptors provide survival, proliferation, and invasion characteristics to CaP cells in both primary sites of cancer and metastatic locations. The emerging data demonstrate that many chemokines and their receptors are involved in the multistep process of CaP, leading to metastasis, and, further, that these factors act cooperatively to enhance other mechanisms of tumor cell survival, growth, and metastasis. Changes of chemokine receptor cohorts may be necessary to activate tumor-promoting signals. Chemokine receptors can activate downstream effectors, such as mitogen-activated protein kinases, by complex mechanisms of ligand-dependent activation of cryptic growth factors; guanosine triphosphate–binding, protein-coupled activation of survival kinases; or transactivation of other receptors such as ErbB family members. We describe vanguard research in which more than the classic view of chemokine receptor biology was clarified. Control of chemokines and inhibition of their receptor activation may add critical tools to reduce tumor growth, especially in chemo-hormonal refractory CaP that is both currently incurable and the most aggressive form of the disease, accounting for most of the more than 28,000 annual deaths.
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影响因子：
8.5
作者：
El-Haibi CP;Singh R;Sharma PK;Singh S;Lillard JW Jr
通讯作者：
Lillard JW Jr
DOI：
10.1158/1078-0432.ccr-08-0738
发表时间：
2008-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Caruso DJ;Carmack AJ;Lokeshwar VB;Duncan RC;Soloway MS;Lokeshwar BL
通讯作者：
Lokeshwar BL
影响因子：
4.1
作者：
Kasina, Sathish;Macoska, Jill A.
通讯作者：
Macoska, Jill A.
DOI：
10.1016/j.urolonc.2007.05.010
发表时间：
2007-09-01
影响因子：
2.7
作者：
Hadaschik, Boris A.;Gleave, Martin E.
通讯作者：
Gleave, Martin E.
影响因子：
4.8
作者：
Begley, Lesa A.;MacDonald, James W.;Macoska, Jill A.
通讯作者：
Macoska, Jill A.