Homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen.
Homeostatic and endocrine responses as the basis for systemic therapy with medical gases: ozone, xenon and molecular hydrogen.
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DOI：
10.4103/2045-9912.318863
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发表时间：
2021-10
影响因子：
2.9
通讯作者：
Noda M
中科院分区：
文献类型：
--
作者：
Nazarov EI;Khlusov IA;Noda M
在医用气体中，包括用于治疗的气体，本文讨论了三种气体的比较生理活性-臭氧（O3），氙（Xe）和分子氢（H2），它们共同构成了三种类型的物质的代表-典型的氧化剂，惰性剂和典型的还原剂。通过分析已发表和专有数据，我们得出结论，这三种医用气体可以通过下丘脑-垂体-肾上腺、下丘脑-垂体-甲状腺、下丘脑-垂体-性腺轴或胃肠道途径调节激素的产生或释放，从而操纵神经内分泌系统。随着时间的推移，随着气体的重复给药，这些调节成为条件稳态反射的可预测结果，导致生理活动的调节。例如，在臭氧反复中毒时，非条件防御反射的定期激活会导致形成预期的稳定条件反应，从而抵消O3的毒性作用。巴甫洛夫条件反射（或hormoligosis）的概念是理解全身臭氧治疗效果的一个简短的比喻。
Among medical gases, including gases used therapeutically, this review discusses the comparative physiological activity of three gases – ozone (O3), xenon (Xe) and molecular hydrogen (H2), which together form representatives of three types of substances – typical oxidizing, inert, and typical reducing agents. Upon analysis of published and proprietary data, we concluded that these three medical gases can manipulate the neuroendocrine system, by modulating the production or release of hormones via the hypothalamic-pituitary-adrenal, hypothalamic-pituitary-thyroid, hypothalamic-pituitary-gonadal axes, or the gastrointestinal pathway. With repeated administration of the gases over time, these modulations become a predictable consequence of conditioned homeostatic reflexes, resulting in regulation of physiological activity. For example, the regular activation of the unconditioned defense reflex in response to repeated intoxication by ozone leads to the formation of an anticipatory stable conditioned response, which counteracts the toxic action of O3. The concept of a Pavlovian conditioned reflex (or hormoligosis) is a brief metaphor for the understanding the therapeutic effect of systemic ozone therapy.
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DOI：
10.1523/jneurosci.3890-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrews ZB;Erion D;Beiler R;Liu ZW;Abizaid A;Zigman J;Elsworth JD;Savitt JM;DiMarchi R;Tschoep M;Roth RH;Gao XB;Horvath TL
通讯作者：
Horvath TL
影响因子：
4.7
作者：
Begum, Rahima;Bajgai, Johny;Lee, Kyu-Jae
通讯作者：
Lee, Kyu-Jae
影响因子：
3.3
作者：
Ader R;Mercurio MG;Walton J;James D;Davis M;Ojha V;Kimball AB;Fiorentino D
通讯作者：
Fiorentino D
影响因子：
--
作者：
Asvold, Bjorn O.;Bjoro, Trine;Vatten, Lars J.
通讯作者：
Vatten, Lars J.
影响因子：
2.9
作者：
Bocci V;Zanardi I;Travagli V
通讯作者：
Travagli V