Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory
Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory
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外侧内嗅皮层第二层的扇形细胞对于情景记忆至关重要
DOI：
10.1016/j.cub.2019.11.027
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发表时间：
2020
期刊：
影响因子：
9.2
通讯作者：
Vandrey B
中科院分区：
文献类型：
--
作者：
Vandrey B
情景记忆需要不同类型的信息结合在一起，以产生经验的表征。外侧内嗅皮层（LEC）和海马是啮齿类动物的情节样记忆所必需的[1，2]。LEC对于整合有关对象的空间和上下文信息至关重要[2-6]。此外，LEC神经元编码环境中的对象和对象先前经历的位置，并在编码和检索事件期间生成时间表示[7-12]。然而，目前还不清楚LEC内的特定细胞群如何促进情景记忆成分的整合。LEC的第2层（L2）在阿尔茨海默病（AD）和相关动物模型中表现出早期病理学[13-16]。从LEC的L2到海马的投射来自表面亚层（L2 a）中的扇形细胞，其对reelin具有免疫反应性并投射到齿状回[17，18]。在这里，我们建立了一种方法，选择性地针对风扇细胞使用Sim 1：Cre小鼠。鉴于LEC的完全损伤以前被发现消除关联识别记忆[2，3]，我们报告说，在选择性抑制来自扇形细胞的突触输出后，小鼠可以区分新的物体-背景配置，但在识别新的物体-位置-背景关联时受损。我们的研究结果表明，不同的LEC网络之间的记忆功能分离。
Episodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents [1, 2]. The LEC is critical for integrating spatial and contextual information about objects [2–6]. Further, LEC neurons encode objects in the environment and the locations where objects were previously experienced and generate representations of time during the encoding and retrieval of episodes [7–12]. However, it remains unclear how specific populations of cells within the LEC contribute to the integration of episodic memory components. Layer 2 (L2) of LEC manifests early pathology in Alzheimer's disease (AD) and related animal models [13–16]. Projections to the hippocampus from L2 of LEC arise from fan cells in a superficial sub-layer (L2a) that are immunoreactive for reelin and project to the dentate gyrus [17, 18]. Here, we establish an approach for selectively targeting fan cells using Sim1:Cre mice. Whereas complete lesions of the LEC were previously found to abolish associative recognition memory [2, 3], we report that, after selective suppression of synaptic output from fan cells, mice can discriminate novel object-context configurations but are impaired in recognition of novel object-place-context associations. Our results suggest that memory functions are segregated between distinct LEC networks.
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DOI：
10.1126/science.aac9462
发表时间：
2015-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang X;Shen S;Cadwell CR;Berens P;Sinz F;Ecker AS;Patel S;Tolias AS
通讯作者：
Tolias AS
影响因子：
14.5
作者：
Parra, Mario A.;Abrahams, Sharon;Della Sala, Sergio
通讯作者：
Della Sala, Sergio
影响因子：
3.5
作者：
Canto, Cathrin B.;Witter, Menno P.
通讯作者：
Witter, Menno P.
影响因子：
3.7
作者：
Stranahan, Alexis M.;Haberman, Rebecca P.;Gallagher, Michela
通讯作者：
Gallagher, Michela
干扰外侧内嗅皮层的 reelin 信号传导会损害空间记忆
影响因子：
2.7
作者：
A. Stranahan;Sebastian Salas;N. Jiam;M. Gallagher
通讯作者：
M. Gallagher