Potential epigenetic mechanism(s) associated with the persistence of psychoneurological symptoms in women receiving chemotherapy for breast cancer: a hypothesis.
Potential epigenetic mechanism(s) associated with the persistence of psychoneurological symptoms in women receiving chemotherapy for breast cancer: a hypothesis.
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DOI：
10.1177/1099800413483545
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发表时间：
2014-04
影响因子：
2.5
通讯作者：
Jackson-Cook C
中科院分区：
文献类型：
--
作者：
Lyon D;Elmore L;Aboalela N;Merrill-Schools J;McCain N;Starkweather A;Elswick RK Jr;Jackson-Cook C
由于最近的治疗进展，乳腺癌（BC）诊断后幸存的妇女比例有所改善。然而，这些幸存者中的许多人在治疗后报告了持续的不良副作用，如认知功能障碍、抑郁症状、焦虑、疲劳、睡眠障碍和疼痛。研究人员检查了炎症标志物的循环水平，特别是血清细胞因子，以寻找与这些精神神经症状（PNS）的发展/持续存在的潜在因果关系。虽然由感知压力或其他因素引起的炎症激活可能直接导致PNS的发展，但我们提出了另一种假设，认为这些症状是一系列生物学变化的早期步骤，导致脱氧核糖核酸（DNA）甲基化、组蛋白修饰和/或染色质结构/染色体不稳定水平的表观遗传改变。鉴于表观遗传模式具有可塑性，如果表观基因组/获得性基因组改变与PNS的发展/持续之间的这种推测关系得到证实，它可以为未来的研究提供基础知识，从而识别预测标记物和/或治疗方法来缓解BC女性的PNS。在本文中，我们讨论了PNS生物学基础的一个不断发展的理论，整合了遗传和表观遗传科学背景下与炎症和DNA修复相关的知识，以扩展理解化疗后症状获得/持续的范式。
Due to recent treatment advances, there have been improvements in the proportion of women surviving a diagnosis of breast cancer (BC). However, many of these survivors report persistent adverse side effects following treatment, such as cognitive dysfunction, depressive symptoms, anxiety, fatigue, sleep disturbances, and pain. Investigators have examined circulating levels of inflammatory markers, particularly serum cytokines, for a potential causal relationship to the development/persistence of these psychoneurological symptoms (PNS). While inflammatory activation, resulting from perceived stress or other factors, may directly contribute to the development of PNS, we offer an alternative hypothesis, suggesting that these symptoms are an early step in a cascade of biological changes leading to epigenetic alterations at the level of deoxyribonucleic acid (DNA) methylation, histone modifications, and/or chromatin structure/chromosomal instability. Given that epigenetic patterns have plasticity, if this conjectured relationship between epigenomic/acquired genomic alterations and the development/persistence of PNS is confirmed, it could provide foundational knowledge for future research leading to the recognition of predictive markers and/or treatments to alleviate PNS in women with BC. In this article, we discuss an evolving theory of the biological basis of PNS, integrating knowledge related to inflammation and DNA repair in the context of genetic and epigenetic science to expand the paradigm for understanding symptom acquisition/persistence following chemotherapy.
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EZH2- 介导的表观遗传学抑制 DNA 修复，促进乳腺肿瘤始发细胞的生长。
DOI：
10.1186/bcr2871
发表时间：
2011-05-25
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Stefansson OA;Esteller M
通讯作者：
Esteller M
影响因子：
2.7
作者：
Day, Jeremy J;Sweatt, J David
通讯作者：
Sweatt, J David
影响因子：
50.3
作者：
Chang CJ;Yang JY;Xia W;Chen CT;Xie X;Chao CH;Woodward WA;Hsu JM;Hortobagyi GN;Hung MC
通讯作者：
Hung MC
影响因子：
2.3
作者：
Bartsch, Helmut;Nair, Jagadeesan
通讯作者：
Nair, Jagadeesan
影响因子：
8.4
作者：
Butcher, Darci T.;Rodenhiser, David I.
通讯作者：
Rodenhiser, David I.