Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.
Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.
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DOI：
10.1016/j.neuint.2017.04.009
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发表时间：
2017-10
影响因子：
4.2
通讯作者：
Hardwick JM
中科院分区：
文献类型：
--
作者：
Aouacheria A;Baghdiguian S;Lamb HM;Huska JD;Pineda FJ;Hardwick JM
线粒体群体的形态是几种相互作用的动力学现象的结果，包括裂变、融合、运动、消除和生物发生。这些现象中的每一种都是由潜在的分子机制控制的，当有缺陷时会导致疾病。线粒体在健康和疾病中的形式和功能之间的关系的新认识开始在几个方面被解开。在哺乳动物和模式生物中的研究已经揭示，线粒体形态、动力学和功能似乎受到调节凋亡性细胞死亡的相同蛋白质的调节。影响健康和垂死细胞中线粒体动力学的一个蛋白质家族是Bcl-2蛋白质家族。将线粒体动力学与生死通路叉连接起来可能是由于Bcl-2家族蛋白与决定线粒体形状和功能的蛋白质和脂质的交叉。Bcl-2家族蛋白也对细胞和线粒体具有多方面的影响，包括钙处理、自噬和能量学，以及线粒体细胞器到神经元突触的亚细胞定位。Bcl-2家族蛋白的物理或功能相互作用的显着范围是具有挑战性的同化到一个有凝聚力的理解。它们的大多数作用可能与它们在凋亡性细胞死亡中的直接作用不同，并且在神经系统中特别明显。在线粒体动力学和细胞死亡中的双重作用超出了BCL-2家族蛋白。在这篇综述中，我们讨论了许多过程中，管理健康和疾病的线粒体结构和功能，以及Bcl-2家族蛋白如何整合到这些过程中的一些。
The morphology of a population of mitochondria is the result of several interacting dynamical phenomena, including fission, fusion, movement, elimination and biogenesis. Each of these phenomena is controlled by underlying molecular machinery, and when defective can cause disease. New understanding of the relationships between form and function of mitochondria in health and disease is beginning to be unraveled on several fronts. Studies in mammals and model organisms have revealed that mitochondrial morphology, dynamics and function appear to be subject to regulation by the same proteins that regulate apoptotic cell death. One protein family that influences mitochondrial dynamics in both healthy and dying cells is the Bcl-2 protein family. Connecting mitochondrial dynamics with life-death pathway forks may arise from the intersection of Bcl-2 family proteins with the proteins and lipids that determine mitochondrial shape and function. Bcl-2 family proteins also have multifaceted influences on cells and mitochondria, including calcium handling, autophagy and energetics, as well as the subcellular localization of mitochondrial organelles to neuronal synapses. The remarkable range of physical or functional interactions by Bcl-2 family proteins is challenging to assimilate into a cohesive understanding. Most of their effects may be distinct from their direct roles in apoptotic cell death and are particularly apparent in the nervous system. Dual roles in mitochondrial dynamics and cell death extend beyond BCL-2 family proteins. In this review, we discuss many processes that govern mitochondrial structure and function in health and disease, and how Bcl-2 family proteins integrate into some of these processes.
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影响因子：
19
作者：
Aouacheria A;Rech de Laval V;Combet C;Hardwick JM
通讯作者：
Hardwick JM
影响因子：
16
作者：
Bhola PD;Letai A
通讯作者：
Letai A
影响因子：
21.3
作者：
通讯作者：
--
DOI：
10.1083/jcb.201401070
发表时间：
2014-09-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ashrafi G;Schlehe JS;LaVoie MJ;Schwarz TL
通讯作者：
Schwarz TL
影响因子：
13.8
作者：
Aouacheria, Abdel;Combet, Christophe;Tompa, Peter;Hardwick, J. Marie
通讯作者：
Hardwick, J. Marie