Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles.
Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles.
复制标题
DOI：
10.1371/journal.pone.0024374
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Mukherjee P
中科院分区：
文献类型：
--
作者：
Arvizo RR;Miranda OR;Moyano DF;Walden CA;Giri K;Bhattacharya R;Robertson JD;Rotello VM;Reid JM;Mukherjee P
无机纳米粒子为生物医学应用提供了有前途的工具，包括检测，诊断和治疗。虽然表面性质，如电荷，预计在其体内行为中发挥重要作用，但很少有人知道纳米颗粒的表面化学如何影响其药代动力学，肿瘤摄取和生物分布。使用一系列结构同源的纳米颗粒，我们研究了包括肿瘤摄取和生物分布在内的药理学性质如何受到中性（TEGOH）、两性离子（Tzwit）、负性（TCOOH）和正性（TTMA）纳米颗粒表面电荷的影响。将纳米颗粒在尾静脉或腹膜中注射到小鼠（正常和无胸腺）中。中性和两性离子纳米颗粒通过IP和IV给药表现出更长的循环时间，而带负电和带正电的纳米颗粒具有相对较短的半衰期。这些药理学特征反映在相应纳米颗粒的肿瘤摄取和生物分布上，中性和两性离子纳米颗粒通过被动靶向增强肿瘤摄取。
Inorganic nanoparticles provide promising tools for biomedical applications including detection, diagnosis and therapy. While surface properties such as charge are expected to play an important role in their in vivo behavior, very little is known how the surface chemistry of nanoparticles influences their pharmacokinetics, tumor uptake, and biodistribution. Using a family of structurally homologous nanoparticles we have investigated how pharmacological properties including tumor uptake and biodistribution are influenced by surface charge using neutral (TEGOH), zwitterionic (Tzwit), negative (TCOOH) and positive (TTMA) nanoparticles. Nanoparticles were injected into mice (normal and athymic) either in the tail vein or into the peritoneum. Neutral and zwitterionic nanoparticles demonstrated longer circulation time via both IP and IV administration, whereas negatively and positively charged nanoparticles possessed relatively short half-lives. These pharmacological characteristics were reflected on the tumor uptake and biodistribution of the respective nanoparticles, with enhanced tumor uptake by neutral and zwitterionic nanoparticles via passive targeting.
登录
查看更多内容
影响因子：
15
作者：
Agasti SS;Chompoosor A;You CC;Ghosh P;Kim CK;Rotello VM
通讯作者：
Rotello VM
影响因子：
21.8
作者：
通讯作者：
--
影响因子：
15
作者：
Gao, Jinhao;Liang, Gaolin;Xu, Bing
通讯作者：
Xu, Bing
影响因子：
2.9
作者：
Mukherjee, Priyabrata;Bhattacharya, Resham;Mukhopadhyay, Debabrata
通讯作者：
Mukhopadhyay, Debabrata
影响因子：
4.9
作者：
Kanaras, AG;Kamounah, FS;Brust, M
通讯作者：
Brust, M