Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen‐presenting cells and promotes resistance to Salmonella infection
Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen‐presenting cells and promotes resistance to Salmonella infection
复制标题
信号淋巴细胞激活分子家族成员 9 存在于选定的抗原呈递细胞亚群中，可促进对沙门氏菌感染的抵抗力
DOI：
10.1111/imm.13169
复制
发表时间：
2020
期刊：
影响因子：
6.4
通讯作者：
Smith, Kenneth G.
中科院分区：
文献类型：
--
作者：
Wilson, Timothy J.;Clare, Simon;Mikulin, Joseph;Johnson, Christopher M.;Harcourt, Katherine;Lyons, Paul A.;Dougan, Gordon;Smith, Kenneth G.
信号淋巴细胞活化分子家族成员9（SLAMF 9）是白细胞表面蛋白的CD 2/SLAM家族的孤儿受体。对SLAMF 9表达和功能的检查表明，SLAMF 9通过抗原呈递细胞的特化亚群促进炎症。在健康肝脏和循环小鼠外周血单核细胞中，SLAMF 9在CD 11b+、Ly 6C −、CD 11 clow、F4/80 low、MHC-II+、CX 3CR 1+单核吞噬细胞以及浆细胞样树突状细胞上表达。此外，可以在腹膜B1细胞和小（F4/80低）但不大（F4/80高）的腹膜巨噬细胞上发现SLAMF 9。在用肠道沙门氏菌（Salmonella entericaTyphimurium）进行全身性攻击后，Slamf 9 −/−小鼠清除肝脏感染的能力受损。在人类中，SLAMF 9在单核细胞分化为巨噬细胞后上调，PMA分化的脂多糖刺激，SLAMF 9敲减的THP-1细胞显示SLAMF 9在粒细胞-巨噬细胞集落刺激因子、肿瘤坏死因子-α和白细胞介素-1 β的产生中起重要作用。总之，这些数据表明SLAMF 9参与炎症的起始和细菌感染的清除。
Signalling lymphocyte activation molecule family member 9 (SLAMF9) is an orphan receptor of the CD2/SLAM family of leucocyte surface proteins. Examination of SLAMF9 expression and function indicates that SLAMF9 promotes inflammation by specialized subsets of antigen‐presenting cells. Within healthy liver and circulating mouse peripheral blood mononuclear cells, SLAMF9 is expressed on CD11b+, Ly6C−, CD11clow, F4/80low, MHC‐II+, CX3CR1+mononuclear phagocytes as well as plasmacytoid dendritic cells. In addition, SLAMF9 can be found on peritoneal B1 cells and small (F4/80low), but not large (F4/80high), peritoneal macrophages. Upon systemic challenge withSalmonella entericaTyphimurium,Slamf9−/−mice were impaired in their ability to clear the infection from the liver. In humans, SLAMF9 is up‐regulated upon differentiation of monocytes into macrophages, and lipopolysaccharide stimulation of PMA‐differentiated, SLAMF9 knockdown THP‐1 cells showed an essential role of SLAMF9 in production of granulocyte–macrophage colony‐stimulating factor, tumour necrosis factor‐α, and interleukin‐1β. Taken together, these data implicate SLAMF9 in the initiation of inflammation and clearance of bacterial infection.
登录
查看更多内容
DOI：
10.3791/3881
发表时间：
2012-03-05
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Kerr JS;Wright GJ
通讯作者：
Wright GJ
CD229 (Ly9) 淋巴细胞表面受体通过其 N 端结构域发生同源相互作用并重新定位至免疫突触 1
影响因子：
4.4
作者：
X. Romero;N. Zapater;M. Calvo;S. Kalko;M. A. de la Fuente;V. Tovar;C. Ockeloen;P. Pizcueta;P. Engel
通讯作者：
P. Engel
影响因子：
4.4
作者：
B. Garni-Wagner;A. Purohit;P. A. Mathew;M. Bennett;V. Kumar
通讯作者：
B. Garni-Wagner;A. Purohit;P. A. Mathew;M. Bennett;V. Kumar
前沿技术：NTB-A 通过同质相互作用激活 NK 细胞1
影响因子：
4.4
作者：
R. Flaig;S. Stark;C. Watzl
通讯作者：
C. Watzl
SLAM 家族受体信号传导的精细特异性和分子竞争
影响因子：
3.7
作者：
T. Wilson;Lee Garner;C. Metcalfe;Elliott King;S. Margraf;Marion H. Brown
通讯作者：
Marion H. Brown