Cutting Edge: NTB-A Activates NK Cells via Homophilic Interaction1
Cutting Edge: NTB-A Activates NK Cells via Homophilic Interaction1
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前沿技术：NTB-A 通过同质相互作用激活 NK 细胞1
作者：
R. Flaig;S. Stark;C. Watzl
NK细胞是先天免疫系统的重要组成部分。它们的活性受到激活和抑制性表面受体的严格调节。然而，许多活化表面受体及其配体的确切功能仍有待阐明。NTB-A是人NK、T和B细胞表面上的受体，介导其功能障碍可能涉及X连锁淋巴增生性疾病的信号。然而，NTB-A的配体迄今为止仍然难以捉摸。使用三聚体重组蛋白，我们现在表明NTB-A是它自己的配体。NTB-A的嗜同性相互作用增强NK细胞的细胞毒性并影响NK细胞增殖和IFN-γ分泌。我们认为NTB-A是一种淋巴细胞间的信号分子，它可以协调免疫细胞的活动。
NK cells are an important component of the innate immune system. Their activity is tightly regulated by activating and inhibitory surface receptors. However, the exact functions of many activating surface receptors, as well as their ligands, still remain to be elucidated. NTB-A is a receptor on the surfaces of human NK, T, and B cells, mediating a signal whose malfunction may be involved in X-linked lymphoproliferative disease. However, the ligand of NTB-A has remained elusive so far. Using trimeric recombinant proteins, we now show that NTB-A is its own ligand. Homophilic interaction of NTB-A enhances NK cell cytotoxicity and influences NK cell proliferation and IFN-γ secretion. We suggest that NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.
通过 KIR2D 单克隆抗体检测到多克隆自然杀伤细胞上杀伤细胞免疫球蛋白样受体 (KIR) 的均匀表达。
影响因子：
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作者：
Watzl,C;Peterson,M;Long,EO
通讯作者：
Long,EO