Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.

Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.
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DOI:
10.3389/fpsyt.2020.532606
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发表时间:
2020
影响因子:
4.7
通讯作者:
Wemmie JA
Wemmie JA
中科院分区:
医学3区
文献类型:
--
作者:
Shaffer JJ Jr;Mani M;Schmitz SL;Xu J;Owusu N;Wu D;Magnotta VA;Wemmie JA

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质子交换为磁共振成像 (MRI) 提供了强大的对比机制。对质子交换敏感的 MRI 技术提供了新的机会,以高空间和时间分辨率绘制对大脑代谢和功能重要的化合物。化学交换饱和转移 (CEST) 和旋转坐标系中的 T1 弛豫 (T1ρ) 这两种技术正在成为神经和精神疾病研究中研究大脑代谢的有前景的工具。这篇综述为非专家介绍了质子交换,强调了质子交换 MRI 的现状,并介绍了这些技术与更传统的脑代谢成像方法(包括正电子发射断层扫描 (PET) 和磁共振波谱 (MRS))相比的优点和缺点。最后,这篇综述强调了 CEST 和 T1ρ 在大脑研究中的应用新领域。
Proton exchange provides a powerful contrast mechanism for magnetic resonance imaging (MRI). MRI techniques sensitive to proton exchange provide new opportunities to map, with high spatial and temporal resolution, compounds important for brain metabolism and function. Two such techniques, chemical exchange saturation transfer (CEST) and T1 relaxation in the rotating frame (T1ρ), are emerging as promising tools in the study of neurological and psychiatric illnesses to study brain metabolism. This review describes proton exchange for non-experts, highlights the current status of proton-exchange MRI, and presents advantages and drawbacks of these techniques compared to more traditional methods of imaging brain metabolism, including positron emission tomography (PET) and MR spectroscopy (MRS). Finally, this review highlights new frontiers for the use of CEST and T1ρ in brain research.
来自Z频谱拟合的2ppm(CEST@2ppm)处的CEST信号与脑肿瘤中的肌酸分布相关。
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