Mechanical effects of obesity on central and peripheral airway resistance in nonasthmatic early pubescent children.
Mechanical effects of obesity on central and peripheral airway resistance in nonasthmatic early pubescent children.
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DOI：
10.1002/ppul.26111
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发表时间：
2022-12
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
--
作者：
In children, obesity typically reduces functional residual capacity (FRC), which reduces airway caliber and increases airway resistance. Whether these obesity-related changes in respiratory function can alter bronchodilator responsiveness is unknown. To investigate bronchodilator responsiveness in nonasthmatic children with and without obesity. 70 nonasthmatic children, 8 – 12 years old, without (n=19) and with (n=51) obesity, completed spirometry, impulse oscillometry, and airway resistance measurements through plethysmography pre/post 360 μg of inhaled albuterol. FRC was assessed pre albuterol. A two-way ANOVA determined the effects of obesity (group) and inhaled albuterol (pre-post) on outcome measures. FRC (%total lung capacity) was 16% lower in children with obesity compared with those without obesity. There was no significant group by pre-post albuterol interaction on any outcome variables. Albuterol inhalation reduced total, central and peripheral airway resistance and increased airway reactance (i.e., less negative) to a similar degree in children with and without obesity. In children with obesity, airway resistance was increased whether measured by impulse oscillometry or plethysmography. However, once airway resistance was adjusted for lung volumes (i.e., specific airway resistance or sRaw), there were no differences between children with and without obesity. In addition, significant but moderate associations were detected between chest mass and FRC (r=−0.566;P<0.001), FRC and total airway resistance (i.e., Raw; r=−0.445;P<0.001). In nonasthmatic early pubescent children, obesity increases total, central, and peripheral respiratory system resistance. However, the added respiratory system resistance and low lung volume breathing with obesity are not sufficient to reduce bronchodilator responsiveness.
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影响因子：
6.9
作者：
Kalhoff, Hermann;Breidenbach, Renate;Marek, Wolfgang
通讯作者：
Marek, Wolfgang
影响因子：
24.3
作者：
Coates, AL;Peslin, R;Stocks, J
通讯作者：
Stocks, J
DOI：
10.1183/20734735.020514
发表时间：
2015-03
期刊：
Breathe (Sheffield, England)
影响因子：
--
作者：
Brashier B;Salvi S
通讯作者：
Salvi S
影响因子：
15.9
作者：
BRISCOE, WA;DUBOIS, AB
通讯作者：
DUBOIS, AB
影响因子：
10
作者：
Ekström S;Hallberg J;Kull I;Protudjer JLP;Thunqvist P;Bottai M;Gustafsson PM;Bergström A;Melén E
通讯作者：
Melén E