Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study.
Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study.
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DOI：
10.1136/thoraxjnl-2017-210716
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发表时间：
2018-06
期刊：
影响因子：
10
通讯作者：
Melén E
中科院分区：
文献类型：
--
作者：
Ekström S;Hallberg J;Kull I;Protudjer JLP;Thunqvist P;Bottai M;Gustafsson PM;Bergström A;Melén E
很少有大型前瞻性研究调查了儿童时期体重指数（BMI）对肺功能的影响。使用2002年至2013年收集的数据，我们分析了BAMSE队列（n=2889）中8至16岁BMI状态与肺功能（通过肺功能测定法评估）之间的相关性，以及16岁时与小气道功能（脉冲肺功能测定法）的横断面相关性。在16岁时，通过分析FENO、血嗜酸性粒细胞和中性粒细胞，研究局部和全身炎症的横断面相关性。8岁时超重和肥胖与FVC较高相关，但8岁和16岁时FEV 1/FVC比值较低。在男孩中，而不是女孩，8岁时的肥胖与8至16岁之间FEV 1/FVC的进一步降低相关。在横断面分析中，超重和肥胖与16岁时较高的电阻频率依赖性（R5-20）和较大的电抗曲线下面积（AX0.5）相关。在超重和肥胖的女孩中观察到血液中性粒细胞计数增加，但在男孩中没有。BMI状态和FENO之间没有发现关联。与持续正常体重相比，8 - 16岁之间持续性但非短暂性的超重/肥胖与16岁时较高的R5-20和AX 0.5以及较低的FEV 1/FVC（女孩为-2.8%（95%CI-4.1至-1.2），男孩为-2.7%（95%CI-4.4至-1.1））相关。在儿童和青少年时期，超重和肥胖，特别是持续超重，与气道阻塞（包括小气道）有关。
Few large prospective studies have investigated the impact of body mass index (BMI) on lung function during childhood. Using data collected between 2002 and 2013, we analysed associations between BMI status and lung function (assessed by spirometry) from 8 to 16 years, as well as cross-sectional associations with small airway function (impulse oscillometry) at 16 years in the BAMSE cohort (n=2889). At 16 years, cross-sectional associations with local and systemic inflammation were investigated by analysing FENO, blood eosinophils and neutrophils. Overweight and obesity at 8 years were associated with higher FVC, but lower FEV1/FVC ratio at 8 and 16 years. In boys, but not girls, obesity at 8 years was associated with a further reduction in FEV1/FVC between 8 and 16 years. In cross-sectional analyses, overweight and obesity were associated with higher frequency dependence of resistance (R5–20) and larger area under the reactance curve (AX0.5) at 16 years. Increased blood neutrophil counts were seen in overweight and obese girls, but not in boys. No association was found between BMI status and FENO. Persistent, but not transient, overweight/obesity between 8 and 16 years was associated with higher R5–20 and AX0.5 and lower FEV1/FVC (−2.8% (95% CI −4.1 to −1.2) in girls and −2.7% (95% CI −4.4 to −1.1) in boys) at 16 years, compared with persistent normal weight. In childhood and adolescence, overweight and obesity, particularly persistent overweight, were associated with evidence of airway obstruction, including the small airways.
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3-95 岁年龄范围的多种族肺活量测定参考值：2012 年全球肺功能方程。
DOI：
10.1183/09031936.00080312
发表时间：
2012-12
期刊：
The European respiratory journal
影响因子：
--
作者：
Quanjer PH;Stanojevic S;Cole TJ;Baur X;Hall GL;Culver BH;Enright PL;Hankinson JL;Ip MS;Zheng J;Stocks J;ERS Global Lung Function Initiative
通讯作者：
ERS Global Lung Function Initiative
影响因子：
3.7
作者：
Cibella, Fabio;Bruno, Andreina;Viegi, Giovanni
通讯作者：
Viegi, Giovanni
影响因子：
12.4
作者：
Ballardini, N.;Kull, I.;Wickman, M.
通讯作者：
Wickman, M.
影响因子：
4.4
作者：
Casas, Maribel;den Dekker, Herman T.;Duijts, Liesbeth
通讯作者：
Duijts, Liesbeth
影响因子：
9.6
作者：
Bickel, Scott;Popler, Jonathan;Eid, Nemr
通讯作者：
Eid, Nemr