BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.
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DOI：
10.1093/nar/gkl010
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发表时间：
2006
影响因子：
14.9
通讯作者：
Deng CX
中科院分区：
文献类型：
--
作者：
Deng CX
乳腺癌相关基因 1 (BRCA1) 的种系突变使女性易患乳腺癌和卵巢癌。 BRCA1 是一种具有多个功能域的大型蛋白质，并与参与许多重要生物过程/途径的众多蛋白质相互作用。越来越多的证据表明，BRCA1 参与细胞周期的所有阶段，并调节细胞周期进程中的有序事件。 BRCA1 缺陷会导致 S 期检查点、G2/M 检查点、纺锤体检查点和中心体重复异常。然而，BRCA1 缺陷引起的遗传不稳定性也会引发细胞对 DNA 损伤的反应，从而阻止细胞增殖并诱导细胞凋亡。因此，除非这种细胞防御被破坏，否则 BRCA1 突变细胞不能进一步发育成完全生长的肿瘤。 BRCA1 在细胞周期检查点、基因组完整性、DNA 损伤反应 (DDR) 和肿瘤进化中的功能分析应有助于我们了解 BRCA1 相关肿瘤发生的机制，以及开发这种致命疾病的治疗方法。
Germline mutations of the breast cancer associated gene 1 (BRCA1) predispose women to breast and ovarian cancers. BRCA1 is a large protein with multiple functional domains and interacts with numerous proteins that are involved in many important biological processes/pathways. Mounting evidence indicates that BRCA1 is involved in all phases of the cell cycle and regulates orderly events during cell cycle progression. BRCA1 deficiency, consequently causes abnormalities in the S-phase checkpoint, the G2/M checkpoint, the spindle checkpoint and centrosome duplication. The genetic instability caused by BRCA1 deficiency, however, also triggers cellular responses to DNA damage that blocks cell proliferation and induces apoptosis. Thus BRCA1 mutant cells cannot develop further into full-grown tumors unless this cellular defense is broken. Functional analysis of BRCA1 in cell cycle checkpoints, genome integrity, DNA damage response (DDR) and tumor evolution should benefit our understanding of the mechanisms underlying BRCA1 associated tumorigenesis, as well as the development of therapeutic approaches for this lethal disease.
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影响因子：
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