Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related diseases.
Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related diseases.
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DOI：
10.1186/s12929-018-0480-y
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发表时间：
2018-11-08
影响因子：
11
通讯作者：
Rudnicka K
中科院分区：
文献类型：
--
作者：
Chmiela M;Walczak N;Rudnicka K
幽门螺杆菌（Helicobacter pylori，H. pylori）在胃炎、胃溃疡和十二指肠溃疡以及胃癌的发病机制中起作用。H.幽门螺杆菌在通过胃上皮屏障的细菌抗原分布中的作用及其在局部和全身宿主炎症和免疫应答的发展中的作用已经被提出。OMV含有多种生物活性化合物，其内化到宿主细胞中，影响信号传导途径并促进胃上皮细胞和免疫活性细胞的凋亡。OMV相关H.幽门螺杆菌毒力因子可加强或下调导致疾病发展的免疫应答。本文综述了H. pylori OMV及其在H. pylori感染，以及H. pylori相关的局部和全身效应。
Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylori in the distribution of bacterial antigens through the gastric epithelial barrier and their role in the development of local and systemic host inflammatory and immune responses has been suggested. OMVs contain various biologically active compounds, which internalize into host cells affecting signaling pathways and promoting apoptosis of gastric epithelial and immunocompetent cells. OMVs-associated H. pylori virulence factors may strengthen or downregulate the immune responses leading to disease development. This review describes the biological importance of H. pylori OMVs and their role in the course of H. pylori infections, as well as H. pylori related local and systemic effects.
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影响因子：
6.7
作者：
Cullen TW;Giles DK;Wolf LN;Ecobichon C;Boneca IG;Trent MS
通讯作者：
Trent MS
SABA是幽门螺杆菌血凝素的H.
影响因子：
6.7
作者：
Aspholm, Marina;Olfat, Farzad O.;Norden, Jenny;Sonden, Berit;Lundberg, Carina;Sjostrom, Rolf;Altraja, Siiri;Odenbreit, Stefan;Haas, Rainer;Wadstrom, Torkel;Engstrand, Lars;Semino-Mora, Cristina;Liu, Hui;Dubois, Andre;Teneberg, Susann;Arnqvist, Anna;Boren, Thomas
通讯作者：
Boren, Thomas
DOI：
10.1073/pnas.90.12.5791
发表时间：
1993-06-15
影响因子：
11.1
作者：
COVACCI, A;CENSINI, S;RAPPUOLI, R
通讯作者：
RAPPUOLI, R
影响因子：
11
作者：
Chang WL;Yeh YC;Sheu BS
通讯作者：
Sheu BS
幽门螺杆菌胃上皮细胞粘附和 CagA 注射的分子机制。
DOI：
10.1186/1478-811x-9-28
发表时间：
2011-11-01
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Backert S;Clyne M;Tegtmeyer N
通讯作者：
Tegtmeyer N