Activation strategies for invariant natural killer T cells.
Activation strategies for invariant natural killer T cells.
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DOI：
10.1007/s00251-016-0944-8
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发表时间：
2016-08
期刊：
影响因子：
3.2
通讯作者：
Brennan PJ
中科院分区：
文献类型：
--
作者：
Kohlgruber AC;Donado CA;LaMarche NM;Brenner MB;Brennan PJ
不变自然杀伤T（iNKT）细胞是一种特殊的T细胞亚群，在宿主防御中发挥重要作用，协调针对多种微生物的先天性和适应性免疫效应反应。由抗原呈递分子CD1d呈递的特定微生物脂质和哺乳动物自身脂质可通过其半恒定的αβ T细胞受体（TCR）激活iNKT细胞。iNKT细胞还组成性表达在识别病原体相关分子模式（PAMP）后通常由抗原呈递细胞（APC）分泌的炎性细胞因子的受体，并且它们可通过这些细胞因子受体与TCR信号联合激活，或者在某些情况下甚至在没有TCR信号的情况下被激活。在感染期间，实验证据表明TCR驱动和细胞因子驱动的机制都有助于iNKT细胞的激活。虽然这两种信号机制的相对贡献可根据感染情况有很大差异，但脂质抗原和PAMP都介导iNKT细胞和APC的相互激活，导致多种其他免疫细胞类型的下游激活以促进病原体清除。在这篇综述中，我们讨论感染期间iNKT细胞激活所涉及的机制，重点关注脂质抗原和PAMP诱导的炎性细胞因子的核心贡献，并强调细菌、病毒和真菌感染期间激活的体内实例。
Invariant natural killer T (iNKT) cells are a specialized T cell subset that plays an important role in host defense, orchestrating both innate and adaptive immune effector responses against a variety of microbes. Specific microbial lipids and mammalian self lipids displayed by the antigen-presenting molecule CD1d can activate iNKT cells through their semi-invariant αβ T cell receptors (TCRs). iNKT cells also constitutively express receptors for inflammatory cytokines typically secreted by antigen-presenting cells (APCs) after recognition of pathogen-associated molecular patterns (PAMPs), and they can be activated through these cytokine receptors either in combination with TCR signals, or in some cases even in the absence of TCR signaling. During infection, experimental evidence suggests that both TCR-driven and cytokine-driven mechanisms contribute to iNKT cell activation. While the relative contributions of these two signaling mechanisms can vary widely depending on the infectious context, both lipid antigens and PAMPs mediate reciprocal activation of iNKT cells and APCs, leading to downstream activation of multiple other immune cell types to promote pathogen clearance. In this review, we discuss the mechanisms involved in iNKT cell activation during infection, focusing on the central contributions of both lipid antigens and PAMP-induced inflammatory cytokines, and highlight in vivo examples of activation during bacterial, viral, and fungal infections.
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影响因子：
82.9
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影响因子：
6.1
作者：
Agarwal, R.;Chakrabarti, A.;Denning, D. W.
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不变的天然杀手T细胞识别微生物危险信号引起的脂质自抗原。
影响因子：
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Brennan, Patrick J.;Tatituri, Raju V. V.;Brigl, Manfred;Kim, Edy Y.;Tuli, Amit;Sanderson, Joseph P.;Gadola, Stephan D.;Hsu, Fong-Fu;Besra, Gurdyal S.;Brenner, Michael B.
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Brenner, Michael B.
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15.3
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通讯作者：
Bendelac, A
影响因子：
30.5
作者：
Brigl, M;Bry, L;Brenner, MB
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Brenner, MB