Nrf2: An all-rounder in depression.
Nrf2: An all-rounder in depression.
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DOI：
10.1016/j.redox.2022.102522
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发表时间：
2022-12
期刊：
影响因子：
11.4
通讯作者：
Wang, Furong
中科院分区：
文献类型：
--
作者：
Zuo, Chengchao;Cao, Huan;Song, Yu;Gu, Zhongya;Huang, Yaqi;Yang, Yuyan;Miao, Jinfeng;Zhu, Liudi;Chen, Jianguo;Jiang, Yongsheng;Wang, Furong
氧化和抗氧化剂之间的平衡对于维持体内平衡至关重要。一旦被破坏，它可能导致各种病理结果和疾病，如抑郁症。氧化应激可导致或加重一系列病理过程，包括线粒体功能障碍、神经炎症、自噬障碍和铁凋亡，这些病理过程已被发现参与抑郁症的发展。抑制氧化应激和相关的病理过程可以帮助改善抑郁症。在这方面，核因子红细胞2相关因子2（Nrf2）在抗氧化防御系统中可能起着举足轻重的作用。nrf2的激活不仅可以调节一系列抗氧化基因的表达，减轻氧化应激及其损伤，而且可以直接调节与上述病理过程相关的基因，对抗相应的改变。因此，以Nrf2为靶点治疗抑郁症具有巨大的潜力。激活Nrf2具有抗抑郁作用，但具体机制尚待阐明。本文综述了Nrf2在抑郁症中的关键作用，重点介绍了Nrf2在抑郁症治疗中调节氧化应激及相关病理过程的可能机制。同时，对以Nrf2为靶点的天然和合成化合物在抑郁症治疗中的应用进行了综述。上述研究为靶向Nrf2治疗抑郁症提供了新的思路，为临床转化提供了广阔的基础。
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once disrupted, it can lead to various pathological outcomes and diseases, such as depression. Oxidative stress can result in or aggravate a battery of pathological processes including mitochondrial dysfunction, neuroinflammation, autophagical disorder and ferroptosis, which have been found to be involved in the development of depression. Inhibition of oxidative stress and related pathological processes can help improve depression. In this regard, the nuclear factor erythroid 2-related factor 2 (Nrf2) in the antioxidant defense system may play a pivotal role. Nrf2 activation can not only regulate the expression of a series of antioxidant genes that reduce oxidative stress and its damages, but also directly regulate the genes related to the above pathological processes to combat the corresponding alterations. Therefore, targeting Nrf2 has great potential for the treatment of depression. Activation of Nrf2 has antidepressant effect, but the specific mechanism remains to be elucidated. This article reviews the key role of Nrf2 in depression, focusing on the possible mechanisms of Nrf2 regulating oxidative stress and related pathological processes in depression treatment. Meanwhile, we summarize some natural and synthetic compounds targeting Nrf2 in depression therapy. All the above may provide new insights into targeting Nrf2 for the treatment of depression and provide a broad basis for clinical transformation.
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影响因子：
--
作者：
Costa LG;Garrick JM;Roquè PJ;Pellacani C
通讯作者：
Pellacani C
影响因子：
11.4
作者：
Cao, Huan;Zuo, Chengchao;Gu, Zhongya;Huang, Yaqi;Yang, Yuyan;Zhu, Liudi;Jiang, Yongsheng;Wang, Furong
通讯作者：
Wang, Furong
影响因子：
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作者：
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通讯作者：
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影响因子：
5.6
作者：
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通讯作者：
Minelli, Alba
影响因子：
8
作者：
Chowdhry, S.;Zhang, Y.;McMahon, M.;Sutherland, C.;Cuadrado, A.;Hayes, J. D.
通讯作者：
Hayes, J. D.