The future of osteoarthritis therapeutics: emerging biological therapy.
The future of osteoarthritis therapeutics: emerging biological therapy.
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DOI：
10.1007/s11926-013-0385-4
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发表时间：
2013-12
影响因子：
5
通讯作者：
Mobasheri, A.
中科院分区：
文献类型：
--
作者：
Mobasheri, A.
关键词：
生物疗法是一个蓬勃发展的研究和开发领域，已被广泛用于治疗慢性类风湿性关节炎(RA)和强直性脊柱炎(AS)。然而，目前还没有经过临床验证的治疗骨性关节炎的生物疗法。慢性骨性关节炎越来越被视为一种炎症性疾病。骨性关节炎在很大程度上被认为是一种“磨损疾病”。然而，这种疾病现在被认为涉及“低级别”炎症和从软骨下骨到关节软骨的血管和神经的生长。这一认识将研究重点放在了针对慢性骨关节炎关节软骨、软骨下骨和滑膜中的促炎介质、血管生成因子和细胞因子的生物疗法的开发和评估上。本文综述了新近出现的治疗骨性关节炎的生物治疗方法，并讨论了近年来涉及血管生成和神经发生的分子靶点，以及基于抗体的治疗、降钙素和促软骨生成的小分子刺激物Kartogenin的进展。
Biological therapy is a thriving area of research and development, and is well established for chronic forms of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, there is no clinically validated biological therapy for osteoarthritis (OA). Chronic forms of OA are increasingly viewed as an inflammatory disease. OA was largely regarded as a “wear and tear disease”. However, the disease is now believed to involve “low grade” inflammation and the growth of blood vessels and nerves from the subchondral bone into articular cartilage. This realization has focused research effort on the development and evaluation of biological therapy that targets proinflammatory mediators, angiogenic factors and cytokines in articular cartilage, subchondral bone and synovium in chronic forms of OA. This review article provides an overview of emerging biological therapy for OA, and discusses recent molecular targets implicated in angiogenesis and neurogenesis and progress with antibody-based therapy, calcitonin, and kartogenin, the small molecule stimulator of chondrogenesis.
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