Inhalation therapy of calcitonin relieves osteoarthritis of the knee.
Inhalation therapy of calcitonin relieves osteoarthritis of the knee.
复制标题
DOI：
10.3346/jkms.2012.27.11.1405
复制
发表时间：
2012-11
影响因子：
4.5
通讯作者：
Alatas O
中科院分区：
文献类型：
--
作者：
Armagan O;Serin DK;Calisir C;Dokumacioglu A;Ozgen M;Oner S;Alatas O
本研究旨在确定鼻用鲑鱼降钙素与运动疗法同时使用时是否对膝骨关节炎 (OA) 的临床症状、血清 NO、IL-1β、基质金属蛋白酶 3、尿 C 末端端肽 II 型胶原 (CTX-II) 水平和 MRI 结果具有额外的有益作用。 50 名女性膝关节 OA 患者被随机分为两组。第一组 (n = 30) 接受 200 IU/天鼻用鲑鱼降钙素和家庭锻炼计划；第二组（n = 20）接受为期 6 个月的家庭锻炼计划。与基线相比,第一组治疗后视觉模拟评分(VAS)、WOMAC疼痛、身体功能评分、20米步行时间(P < 0.001)和WOMAC僵硬评分(P = 0.041)均有显着改善,第二组治疗后步行和静息VAS、WOMAC身体功能评分均有所改善(P = 0.029)。仅在第一组中观察到血清 NO 和尿 CTX-II 水平显着升高（P < 0.001）以及股骨内侧髁面积显着改善（P < 0.05）。 VAS 激活值（P = 0.032）和 NO 水平（P < 0.001）有显着差异，有利于第一组。总之，鼻用鲑鱼降钙素除了对膝骨关节炎患者的症状有已知的作用外，还可能具有软骨保护作用。
This study was conducted to determine if nasal salmon calcitonin has additional beneficial effects on clinical symptoms, serum NO, IL-1β, matrix metalloproteinase 3, urinary C-terminal telopeptide type II collagen (CTX-II) levels and MRI findings in knee osteoarthritis (OA) when used concomitantly with exercise therapy. Fifty female patients with knee OA were randomized into two groups. The first group (n = 30) received 200 IU/day nasal salmon calcitonin and a home exercise program; the second group (n = 20) received a home exercise program for 6 months. Compared with baseline,while significant improvements were observed in visual analogue scale (VAS), WOMAC pain, physical function scores, 20-m walking time (P < 0.001) and WOMAC stiffness score (P = 0.041) in the first group, walking and resting VAS, and WOMAC physical function scores were improved (P = 0.029) in the second group after treatment. Significantly increased levels of serum NO and urinary CTX-II (P < 0.001) and significant improvements in the area of medial femoral condyle (P < 0.05) were noted only in the first group. There were significant differences in VAS activation values (P = 0.032) and NO levels (P < 0.001) in the favor of the first group. In conclusion, nasal salmon calcitonin may have possible chondroprotective effects besides its known effects on symptoms in patients with knee OA.
登录
查看更多内容
影响因子：
2.3
作者：
Sondergaard BC;Madsen SH;Segovia-Silvestre T;Paulsen SJ;Christiansen T;Pedersen C;Bay-Jensen AC;Karsdal MA
通讯作者：
Karsdal MA
影响因子：
2.3
作者：
Takayama B;Kikuchi S;Konno S;Sekiguchi M
通讯作者：
Sekiguchi M
影响因子：
4.8
作者：
Di Nino, DL;Linsenmayer, TF
通讯作者：
Linsenmayer, TF
影响因子：
5.8
作者：
FRANCHIMONT, P;BASSLEER, C;BASSLEER, R
通讯作者：
BASSLEER, R
影响因子：
4.8
作者：
Suzuki, H;Nakamura, I;Suda, T
通讯作者：
Suda, T